Tumor-microenvironment-activated bimetallic oxide nanoplatform for second near-infrared region fluorescence-guided colon tumor surgery and multimodal synergistic therapy

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成果类型：

期刊论文

作者：

Xu, Chao;Zhang, Ziqian;Ying, Yunfei;Li, Siyaqi;Dang, Yongying;...

通讯作者：

Xue, FQ;Liu, Xiaolong;Wang, PY

作者机构：

[Zhang, Ziqian; Xue, Fangqin; Xu, Chao; He, Liangzhen; Xue, FQ] Fuzhou Univ, Affiliated Prov Hosp, Fujian Prov Hosp, Fujian Med Univ,Dept Gastrointestinal Surg,Shengli, Fuzhou 350001, Peoples R China.

[Ying, Yunfei; Wang, Peiyuan; Zhang, Ziqian; Liu, Xiaolong; Dang, Yongying; Li, Siyaqi; Liu, XL] Chinese Acad Sci, Fujian Inst Res Struct Matter, Fuzhou 350002, Peoples R China.

[Liu, Xiaolong; Wang, Peiyuan] Fujian Med Univ, United Innovat Mengchao Hepatobiliary Technol Key, Mengchao Hepatobiliary Hosp, Fuzhou 350025, Peoples R China.

[Ying, Yunfei] Univ South China, Sch Basic Med, Dept Biochem & Mol Biol, Hengyang 421001, Peoples R China.

[Li, Siyaqi] Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Peoples R China.

通讯机构：

[Wang, PY ; Liu, XL] C

[Xue, FQ ] F

Fuzhou Univ, Affiliated Prov Hosp, Fujian Prov Hosp, Fujian Med Univ,Dept Gastrointestinal Surg,Shengli, Fuzhou 350001, Peoples R China.

Chinese Acad Sci, Fujian Inst Res Struct Matter, Fuzhou 350002, Peoples R China.

语种：

英文

关键词：

Fluorescence imaging;Multi ion synergistic;PTT enhanced CDT;Tumor microenvironment;Tumor surgery

期刊：

Journal of Colloid and Interface Science

ISSN：

0021-9797

年：

2025

卷：

692

页码：

137529

DOI：

10.1016/j.jcis.2025.137529

基金类别：

Joint Funds for the Innovation of Science and Technology, Fujian Province [2021Y9022]; Natural Science Foundation of Xiamen City, China [3502Z202373073]; Natural Science Foundation of Fujian Province, China [2023J011166]

机构署名：

本校为其他机构

院系归属：

化学化工学院

药学与生物科学学院

摘要：

Colon cancer, characterized by its high incidence and mortality rates, continues to present a significant challenge in cancer treatment. To address this, we present a novel ZnCe based nanocarrier featuring stacked mesopores and rough surface, indocyanine Green (ICG) is encapsulated within these mesopores (ZnCe&ICG). This innovative nanoplatform demonstrates effective accumulation in tumor regions and can be triggered to generate efficacious reactive oxygen species (ROS) in the weakly acidic and high H 2 O 2 conditions typical of tumor microenvi...

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Tumor-microenvironment-activated bimetallic oxide nanoplatform for second near-infrared region fluorescence-guided colon tumor surgery and multimodal synergistic therapy

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