Tumor Microenvironment Responsive RNA Drug Delivery Systems: Intelligent Platforms for Sophisticated Release

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wang, Guihua;Zhang, Mengxia;Lai, Weiwei;Gao, Yuan;Liao, Shuxian;...

通讯作者：

Tang, SS;Ning, Qian

作者机构：

[Wang, Guihua; Lai, Weiwei; Tang, SS; Tang, Shengsong; Liao, Shuxian] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Gao, Yuan; Wang, Guihua; Lai, Weiwei; Tang, SS; Tang, Shengsong; Ning, Qian; Zhang, Mengxia; Liao, Shuxian] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellige, Huaihua 418000, Peoples R China.

[Zhang, Mengxia] Hunan Univ Chinese Med, Dept Histol & Embryol, Changsha 410128, Peoples R China.

[Tang, SS; Tang, Shengsong; Ning, Qian] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.

通讯机构：

[Tang, SS ] U

[Ning, Q] H

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellige, Huaihua 418000, Peoples R China.

Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.

语种：

英文

关键词：

RNA drug delivery system;tumor microenvironment;stimuli-responsive carrier;gene therapy

期刊：

MOLECULAR PHARMACEUTICS

ISSN：

1543-8384

年：

2024

卷：

期：

页码：

4217-4237

DOI：

10.1021/acs.molpharmaceut.4c00334

基金类别：

Hunan Provincial Science and Technology Plan Key Projects of China [2017SK2183]; Natural Science Foundation of Hunan Province of China [2024JJ7324]; Scientific Research Fund of Hunan Provincial Education Department [23B1042]; Scientific Research Project of Hunan Provincial Health Commission [202113022028]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Cancer is a significant health concern, increasingly showing insensitivity to traditional treatments, highlighting the urgent need for safer and more practical treatment options. Ribonucleic acid (RNA) gene therapy drugs have demonstrated promising potential in preclinical and clinical trials for antitumor therapy by regulating tumor-related gene expression. However, RNA's poor membrane permeability and stability restrict its effectiveness in entering and being utilized in cells. An appropriate delivery system is crucial for achieving targeted tumor effects. The tumor microenvironment (TME), c...

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