Tumor microenvironment based stimuli-responsive CRISPR/Cas delivery systems: A viable platform for interventional approaches

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Tang, Nanyang;Ning, Qian;Wang, Zewei;Tao, Yifang;Zhao, Xuhong;...

通讯作者：

Tang, Shengsong

作者机构：

[Tang, Shengsong; Tao, Yifang; Wang, Zewei; Tang, Nanyang] Univ South China, Sch Pharmaceut Sci, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China.

[Tang, Shengsong; Tao, Yifang; Wang, Zewei; Tang, Nanyang] Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang 421001, Peoples R China.

[Tang, Shengsong; Tao, Yifang; Wang, Zewei; Tang, Nanyang; Zhao, Xuhong; Ning, Qian] Hunan Univ Med, Sch Pharmaceut Sci, Hunan Prov Key Lab Antibody Based Drug & Intellig, Huaihua 418000, Peoples R China.

[Tang, Shengsong; Ning, Qian] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.

通讯机构：

[Tang, Shengsong] U

Univ South China, Sch Pharmaceut Sci, Hunan Prov Key Lab Tumor Microenvironm Respons Dr, Hengyang 421001, Peoples R China.

Univ South China, Inst Pharm & Pharmacol, Sch Pharmaceut Sci, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

CRISPR/Cas;Gene therapy;Stimuli-responsive delivery;Tumor microenvironment

期刊：

Colloids and Surfaces B: Biointerfaces

ISSN：

0927-7765

年：

2022

卷：

210

页码：

112257

DOI：

10.1016/j.colsurfb.2021.112257

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30270684]; Hunan Provincial Science and Technology Plan Key Projects of China [2017SK2183]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2019JJ50416]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [18C1133]; Scientific Research Project of Hunan Provincial Health Commission [202113022028]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas) systems have emerged as robust tools in cancer gene therapy due to their simplicity and versatility. Nevertheless, the genome editing efficiency in tumor sites and the clinical applications of CRISPR/Cas have been compromised by non-specific delivery and genotoxicity. Recently, intelligent delivery systems incorporating sensitive materials in response to endogenous stimuli of the tumor microenvironment (TME) have represented viable platforms f...

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Tumor microenvironment based stimuli-responsive CRISPR/Cas delivery systems: A viable platform for interventional approaches

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