Efficacy of Pgp3 vaccination for Chlamydia urogenital tract infection depends on its native conformation

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成果类型：

期刊论文

作者：

Peng, Bo;Zhong, Shufang;Hua, Yaoqin;Luo, Qizheng;Dong, Weilei;...

通讯作者：

Lu, C.

作者机构：

[Li, Zhongyu; Hua, Yaoqin; Lu, Chunxue; Lei, Aihua; Zhong, Shufang; Peng, Bo; Wang, Chuan; Luo, Qizheng] Univ South China, Inst Pathogen Biol, Hengyang Med Coll, Hunan Prov Key Lab Special Pathogens Prevent & Con, Hengyang, Peoples R China.

[Peng, Bo] Univ South China, Hengyang Med Coll, Dept Pathol, Hengyang, Peoples R China.

[Yang, Chunfen; Dong, Weilei] Univ South China, Dept Obstet & Gynecol, Affiliated Hosp 1, Hengyang, Peoples R China.

通讯机构：

[Lu, C.] I

Institute of Pathogenic Biology, China

语种：

英文

关键词：

Chlamydia trachomatis;conformation structure;histopathology;Pgp3;vaccine

期刊：

FRONTIERS IN IMMUNOLOGY

ISSN：

1664-3224

年：

2022

卷：

页码：

1018774

DOI：

10.3389/fimmu.2022.1018774

基金类别：

This work was supported by the National Natural Science Foundation of China (grant number 81471969), Natural Science Foundation of Hunan Province (grant number 2022JJ30505), Innovation Platform Open Fund Project of Hunan Provincial Education Department (grant number 20K108), and Hunan Province Students’ Innovation and Entrepreneurship Training Program (Xiang Jiao Tong [2022] number 174, grant number S202210555244).

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Urogenital tract infections with Chlamydia trachomatis have frequently been detected among patients diagnosed with sexually transmitted infections, and such infections lead to inflammatory complications. Currently, no licensed chlamydial vaccine is available in clinical practice. We previously reported that immunization with recombinant C. trachomatis plasmid-encoded virulence factor Pgp3 provided cross-serovar protection against C. muridarum genital tract infection. Because Pgp3 is a homotrimer and human antisera only recognize the trimeric fo...

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Efficacy of Pgp3 vaccination for Chlamydia urogenital tract infection depends on its native conformation

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