Astragaloside IV alleviates macrophage senescence and d-galactose-induced bone loss in mice through STING/NF-κB pathway

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成果类型：

期刊论文

作者：

Li, Muzhe;Niu, Yuanyuan;Tian, Linkun;Zhang, Tianchi;Zhou, Shijie;...

通讯作者：

Ma, Yong;Guo, Y

作者机构：

[Zhou, Qinfeng; Niu, Yuanyuan; Wang, Lining; Guo, Yang; Sun, Jie; Ma, Yong; Guo, Y; Tian, Linkun; Li, Muzhe; Wumiti, Taxi; Ma, Y; Zhou, Shijie; Zhang, Tianchi] Nanjing Univ Chinese Med, Lab New Tech Restorat & Reconstruct Orthoped & Tra, Lab New Tech Restorat & Reconstruct, Nanjing 210023, Jiangsu, Peoples R China.

[Wang, Lining; Guo, Yang; Ma, Yong] Nanjing Univ Chinese Med, Wuxi TCM Hosp, Jiangsu CM Clin Innovat Ctr Degenerat Bone & Joint, Nanjing 210023, Jiangsu, Peoples R China.

[Guo, Yang; Ma, Yong; Tian, Linkun; Li, Muzhe; Zhou, Shijie; Zhang, Tianchi] Nanjing Univ Tradit Chinese Med, Affiliated Hosp, Nanjing 210029, Jiangsu, Peoples R China.

[Chen, Zhiwei] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Orthoped, Hengyang 421000, Peoples R China.

通讯机构：

[Ma, Y; Guo, Y ] N

Nanjing Univ Chinese Med, Lab New Tech Restorat & Reconstruct Orthoped & Tra, Lab New Tech Restorat & Reconstruct, Nanjing 210023, Jiangsu, Peoples R China.

语种：

英文

关键词：

AS-IV;Macrophage senescence;NF-κB pathway;SOP;STING

期刊：

International Immunopharmacology

ISSN：

1567-5769

年：

2024

卷：

129

页码：

111588

DOI：

10.1016/j.intimp.2024.111588

基金类别：

CRediT authorship contribution statement Muzhe Li: Writing – original draft. Yuanyuan Niu: Writing – original draft. Linkun Tian: Writing – original draft. Tianchi Zhang: Writing – original draft. Shijie Zhou: Resources. Lining Wang: Project administration. Jie Sun: Supervision. Taxi Wumiti: Supervision. Zhiwei Chen: Writing – review & editing, Supervision. Qinfeng Zhou: Conceptualization. Yong Ma: acquisition. Yang Guo: .

机构署名：

本校为其他机构

摘要：

BACKGROUND: Senile osteoporosis (SOP) is an age-related metabolic bone disease that currently lacks specific therapeutic interventions. Thus, this study aimed to investigate the effect of Astragaloside IV (AS-IV) on macrophage senescence, bone marrow mesenchymal stem cell (BMSC) osteogenesis, and SOP progression. METHODS: A senescent macrophage model was established and treated with varying concentrations of AS-IV. Cell activity was measured using the CCK8 assay. The senescence levels of macrophages were evaluated through β-galactosidase stain...

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Astragaloside IV alleviates macrophage senescence and d-galactose-induced bone loss in mice through STING/NF-κB pathway

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