The research on simulation of human reliability was performed to improve present human reliability analysis methods'deficiencies in time interface, error propagation and others. This paper analyzes the key problems in human reliability simulation such as simulation modeling, simulation algorithm design, random numbers generation, error estimation, and simulation size decision, and gives corresponding rational resolutions. Furthermore, an example of human reliability simulation is presented referring to the widely used THERP+HCR method. The simulation results show that this simulation is more e...