Farnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Deng, Wenyi;Fan, Wenjing;Tang, Tingting;Wan, Hengquan;Zhao, Simin;...

通讯作者：

Qu, SL;Li, JQ

作者机构：

[Zhao, Simin; Deng, Wenyi; Tan, Yao; Qu, Shunlin; Oware, Kwabena Agyare; Wan, Hengquan; Tang, Tingting] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

[Deng, Wenyi] Hainan Med Univ, Inst Clin Med, Affiliated Hosp 2, Haikou 570100, Hainan, Peoples R China.

[Fan, Wenjing] Univ South China, Affiliated Hosp 2, Emergency Dept, Hengyang City 421001, Hunan, Peoples R China.

[Tan, Jieqiong] Cent South Univ, Ctr Med Genet, Sch Life Sci, Changsha 410078, Hunan, Peoples R China.

[Tan, Jieqiong] Cent South Univ, Hunan Key Lab Med Genet, Sch Life Sci, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Qu, SL ] U

[Li, JQ ] C

Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp 2, Dept Liver Transplant, Changsha 410011, Hunan, Peoples R China.

Cent South Univ, Xiangya Hosp 2, Transplant Med Res Ctr, Changsha 410011, Hunan, Peoples R China.

语种：

英文

期刊：

Oxidative Medicine and Cellular Longevity

ISSN：

1942-0900

年：

2022

卷：

2022

DOI：

10.1155/2022/3589525

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81900424, 81670424]; National Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ40258, 2019JJ50502, 2021JJ30602]; Cultivation Fund for Scientific Research of Hainan Medical University [HYPY202002]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Farnesoid X receptors (FXR) are bile acid receptors that play roles in lipid, glucose, and energy homeostasis. Synthetic FXR-specific agonists have been developed for treating nonalcoholic fatty liver disease (NAFLD) patients. However, the detailed mechanism remains unclear. To investigate the effects of FXR on NAFLD and the possible mechanism, FXR-null mice were fed either a normal or a high-fat diet. The FXR-null mice developed hepatomegaly, steatosis, accumulation of lipid droplets in liver cells, glucose metabolism disorder, and elevated se...

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Farnesoid X Receptor Deficiency Induces Hepatic Lipid and Glucose Metabolism Disorder via Regulation of Pyruvate Dehydrogenase Kinase 4

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