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COVID-19 and cognitive impairment: neuroinvasive and blood‒brain barrier dysfunction

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成果类型:
期刊论文
作者:
Chen, Yanting;Yang, Wenren;Chen, Feng;Cui, Lili
通讯作者:
Lili Cui
作者机构:
[Cui, Lili; Chen, Feng; Chen, Yanting] Guangdong Med Univ, Affiliated Hosp, Guangdong Key Lab Age Related Cardiac & Cerebral, Dept Neurol, Zhanjiang 524000, Peoples R China.
[Yang, Wenren] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Trauma Ctr, Hengyang 421002, Peoples R China.
通讯机构:
[Lili Cui] D
Department of Neurology, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
语种:
英文
关键词:
COVID-19;SARS-CoV-2;Neuroinvasion;BBB;Cognitive
期刊:
Journal of Neuroinflammation
ISSN:
1742-2094
年:
2022
卷:
19
期:
1
页码:
1-14
基金类别:
This work was supported by grants from the National Natural Science Foundation of China (No. 82071190 and No. 82101269) to Lili Cui.
机构署名:
本校为其他机构
摘要:
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to a global pandemic. Although COVID-19 was initially described as a respiratory disease, there is growing evidence that SARS-CoV-2 is able to invade the brains of COVID-19 patients and cause cognitive impairment. It has been reported that SARS-CoV-2 may have invasive effects on a variety of cranial nerves, including the olfactory, trigeminal, optic, and vagus nerves, and may spread to other brain regions via infected nerve endin...

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