期刊论文

Advances in the study of chlamydial T3SS effector proteins

中文

中国病原生物学杂志

1673-5234

2018

13

9

1042-1045

10.13350/j.cjpb.180927

No.81572011:国家自然科学基金 31600150:国家自然科学基金 No.2016JJ3103:国家自然科学基金

本校为第一机构

衣原体是一种专性细胞内寄生的革兰氏阴性菌,可在广泛的宿主中引起疾病。衣原体Ⅲ型分泌系统效应蛋白是指衣原体通过Ⅲ型分泌系统（TypeⅢsecretion system,T3SS）分泌的,与其存活及毒力相关的蛋白质。衣原体T3SS效应蛋白对于调控宿主细胞功能具有重要作用,如诱导肌动蛋白细胞骨架的重组,改变宿主细胞信号传导机制和抑制宿主细胞凋亡等。因此,研究衣原体T3SS效应蛋白对研究衣原体的致病机制以及研发衣原体疫苗具有重要意义。

Chlamydia are a group of obligate intracellular Gram-negative bacteria,which can cause many diseases in a wide range of hosts.Chlamydial Type Ⅲ secretion system effector proteins are secreted by Chlamydiathrough the type III secretion system,which are associated with Chlamydial survival and virulence.Chlamydial T3 SS effector proteins play an important role in regulating the functions of host cells,such as inducing actin cytoskeleton reorganization,changing the host cell signal transduction mechanisms and inhibiting the host cell apoptosis.The...