An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Gong, Zhaojian;Yang, Qian;Zeng, Zhaoyang*;Zhang, Wenling;Li, Xiayu;...

通讯作者：

Zeng, Zhaoyang

作者机构：

[Gong, Zhaojian; Li, Xiaoling; Zeng, Zhaoyang; Zhou, Ming; Xiong, Wei; Liao, Qianjin; Chen, Pan; Xiang, Bo; Li, Guiyuan] Cent S Univ, Hunan Canc Hosp, Changsha, Hunan, Peoples R China.

[Gong, Zhaojian; Li, Xiaoling; Zeng, Zhaoyang; Zhou, Ming; Xiong, Wei; Liao, Qianjin; Chen, Pan; Xiang, Bo; Li, Guiyuan] Cent S Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

[Yang, Qian; Gong, Zhaojian; Zhang, Wenling; Li, Xiaoling; Zeng, Zhaoyang; Li, Yong; Zhou, Ming; Xiong, Wei; Xiang, Bo; Li, Guiyuan] Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis, Minist Hlth, Changsha, Hunan, Peoples R China.

[Yang, Qian; Li, Xiaoling; Zeng, Zhaoyang; Zhou, Ming; Xiong, Wei; Deng, Hao; Xiang, Bo; Li, Xiayu; Li, Guiyuan] Cent S Univ, Xiangya Hosp 3, Dis Genome Res Ctr, Hunan Key Lab Nonresolving Inflammat & Canc, Changsha, Hunan, Peoples R China.

通讯机构：

[Zeng, Zhaoyang] C

Cent S Univ, Hunan Canc Hosp, Changsha, Hunan, Peoples R China.

Cent S Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis, Minist Hlth, Changsha, Hunan, Peoples R China.

Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

p53;Nasopharyngeal carcinoma (NPC);microRNAs (miRNAs);mRNAs;Long noncoding RNAs (lncRNAs);Gene regulating network

期刊：

Tumor Biology

ISSN：

1010-4283

年：

2016

卷：

期：

页码：

3683-3695

DOI：

10.1007/s13277-015-4156-x

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81172189, 81272298, 81372907, 81301757, 81472531, 81402009, 81572787, 81528019]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [14JJ1010, 2015JJ1022]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

It has been reported that p53 dysfunction is closely related to the carcinogenesis of nasopharyngeal carcinoma (NPC). Recently, an increasing body of evidence has indicated that microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) participate in p53-associated signaling pathways and, in addition to mRNAs, form a complex regulation network to promote tumor occurrence and progression. The aim of this study was to elucidate the p53-regulated miRNAs, mRNAs, and lncRNAs and their regulating networks in NPC. Firstly, we overexpressed p53 in the NPC cell line HNE2 and performed transcriptomic gene ex...

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An integrative transcriptomic analysis reveals p53 regulated miRNA, mRNA, and lncRNA networks in nasopharyngeal carcinoma

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