Nitric Oxide-Producing Polymorphonuclear Neutrophils Confer Protection Against Chlamydia psittaci in Mouse Lung Infection

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成果类型：

期刊论文

作者：

Luo, Ying;Wang, Cui;Du, Zhaoxiang;Wang, Chuan;Wu, Yimou;...

通讯作者：

Aihua Lei

作者机构：

[Wu, Yimou; Luo, Ying; Lei, Aihua; Wang, Chuan; Wang, Cui; Du, Zhaoxiang] Univ South China, Inst Pathogen Biol, Sch Basic Med Sci, Hengyang Med Sch, Hengyang, Hunan, Peoples R China.

[Wu, Yimou; Luo, Ying; Lei, Aihua; Wang, Chuan; Wang, Cui; Du, Zhaoxiang] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Con, Hengyang, Hunan, Peoples R China.

[Lei, Aihua] Inst Pathogen Biol, 28 Changsheng Western Rd, Hengyang, Peoples R China.

通讯机构：

[Aihua Lei] I

Institute of Pathogenic Biology, School of Basic Medical Sciences, Hengyang Medical School, University of South China , Hengyang, Hunan , China<&wdkj&>Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China , Hengyang, Hunan , China

语种：

英文

关键词：

polymorphonuclear neutrophils;Chlamydia psittaci;inducible NO synthase;lung infection;nitric oxide

期刊：

JOURNAL OF INFECTIOUS DISEASES

ISSN：

0022-1899

年：

2023

卷：

228

期：

页码：

453-463

DOI：

10.1093/infdis/jiad072

基金类别：

Natural Science Foundation of Hunan Province [2021JJ40475, 2022JJ20034]; National Natural Science Foundation of China [81800031]; Research Foundation of Department of Education of Hunan Province [22B0412]; Research Foundation of Health Commission of Hunan Province [202202074638]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Abstract Background Whether polymorphonuclear neutrophils (PMN) exert a protective role upon chlamydial infection by expressing inducible nitric oxide (NO) synthase (iNOS) and producing NO remains unclear. Methods This issue was addressed using BALB/c mice infected with Chlamydia psittaci 6BC strain. Methods included flow cytometry, immunofluorescence, qRT-PCR, and western blot. Results The number of PMN was significantly increased during C. psittaci infection, which was accompanied by increased iNOS expression and NO production...

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Nitric Oxide-Producing Polymorphonuclear Neutrophils Confer Protection Against Chlamydia psittaci in Mouse Lung Infection

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