Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity

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成果类型：

期刊论文

作者：

Han, Lei;Wang, Zijing;Wang, Daqi;Gao, Ziwen;Hu, Shaowei;...

通讯作者：

Shi, Dazhi;Shu, YL

作者机构：

[Shu, Yilai; Han, Lei; Shi, Dazhi; Shi, DZ; Wang, Zijing] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Otorhinolaryngol, Hengyang, Peoples R China.

[Wang, Daqi; Hu, Shaowei; Shu, Yilai; Han, Lei; Wang, Zijing; Gao, Ziwen] Fudan Univ, ENT Inst, Shanghai, Peoples R China.

[Wang, Daqi; Hu, Shaowei; Shu, Yilai; Han, Lei; Wang, Zijing; Gao, Ziwen] Fudan Univ, Eye & ENT Hosp, Dept Otorhinolaryngol, State Key Lab Med Neurobiol, Shanghai, Peoples R China.

[Wang, Daqi; Hu, Shaowei; Shu, Yilai; Han, Lei; Wang, Zijing; Gao, Ziwen] Fudan Univ, MOE Frontiers Ctr Brain Sci, Shanghai, Peoples R China.

[Wang, Daqi; Hu, Shaowei; Shu, Yilai; Han, Lei; Wang, Zijing; Gao, Ziwen] Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China.

通讯机构：

[Shu, YL ; Shi, DZ] U

Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Otorhinolaryngol, Hengyang, Peoples R China.

Fudan Univ, ENT Inst, Shanghai, Peoples R China.

Fudan Univ, Eye & ENT Hosp, Dept Otorhinolaryngol, State Key Lab Med Neurobiol, Shanghai, Peoples R China.

Fudan Univ, MOE Frontiers Ctr Brain Sci, Shanghai, Peoples R China.

语种：

英文

关键词：

aminoglycosides;gene therapy;hair cell;ototoxicity;programmed cell death

期刊：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

ISSN：

2296-634X

年：

2024

卷：

页码：

1305433

DOI：

10.3389/fcell.2023.1305433

基金类别：

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Key R&D Program of China (2020YFA0908201 and 2021YFA1101302), the National Natural Science Foundation of China (82225014, 82171148 and 82192864), the Shuguang Program of Shanghai Education Development Foundation and the Shanghai Municipal Education Commission (20SG08), Natural Science Foundation of Hunan Province (2021JJ70111), The Clinical Medical Technology Innovation Guidance Project of Department of Science and Technology of Hunan Provincial (2021SK51715).

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本校为第一且通讯机构

摘要：

Aminoglycosides are commonly used for the treatment of life-threatening bacterial infections, however, aminoglycosides may cause irreversible hearing loss with a long-term clinical therapy. The mechanism and prevention of the ototoxicity of aminoglycosides are still limited although amounts of studies explored widely. Specifically, advancements in programmed cell death (PCD) provide more new perspectives. This review summarizes the general signal pathways in programmed cell death, including apoptosis, autophagy, and ferroptosis, as well as the mechanisms of aminoglycoside-induced ototoxicity. ...

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Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity

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