Genipin alleviates vascular hyperpermeability following hemorrhagic shock by up-regulation of SIRT3/autophagy

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成果类型：

期刊论文

作者：

Cai Shumin;Xu Wei;Li Yunfeng;Liang Jiangshui;Gao Youguang;...

通讯作者：

Chen Zhongqing;Li Tao

作者机构：

[Xu Wei; Cai Shumin; Chen Zhongqing] Southern Med Univ, Sch Clin Med 1, Nanfang Hosp, Dept Crit Care Med, Guangzhou 510515, Guangdong, Peoples R China.

[Li Yunfeng; Li Tao] Univ South China, Peoples Hosp Chenzhou 1, Dept Crit Care Med, Inst Translat Med, Chenzhou 423000, Peoples R China.

[Liang Jiangshui] Univ South China, Dept Lung Canc Diag, Peoples Hosp Chenzhou 1, Inst Translat Med, Chenzhou 423000, Peoples R China.

[Liang Jiangshui] Univ South China, Treatment Ctr, Peoples Hosp Chenzhou 1, Inst Translat Med, Chenzhou 423000, Peoples R China.

[Gao Youguang] Fujian Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Sch Clin Med 1, 20 Chazhong Rd, Fuzhou 350005, Fujian, Peoples R China.

通讯机构：

[Chen Zhongqing] S

[Li Tao] U

Southern Med Univ, Sch Clin Med 1, Nanfang Hosp, Dept Crit Care Med, Guangzhou 510515, Guangdong, Peoples R China.

Univ South China, Peoples Hosp Chenzhou 1, Dept Crit Care Med, Inst Translat Med, Chenzhou 423000, Peoples R China.

语种：

英文

期刊：

Cell Death Discovery

ISSN：

2058-7716

年：

2018

卷：

期：

页码：

DOI：

10.1038/s41420-018-0057-2

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81500066, 81601708]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2016A030313561]; Natural Science Foundation of Fujian ProvinceNatural Science Foundation of Fujian Province [2016J01451]; Joint Funds for Innovation of Science and Technology of Fujian Province [2016Y9012]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ3015, 2018JJ6006]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Genipin (GP) is commonly used to treat cardiovascular diseases; however, the protective action of GP against vascular hyperpermeability (VH) has not been reported. We previously reported that intrinsic apoptotic signaling (IAS) is involved in VH following hemorrhagic shock (HS). GP inhibits apoptosis, but the specific mechanism remains unclear. In the present study, we observed that GP protects against HS-induced VH in vitro and in vivo. We report that this protective effect is related to the inhibition of IAS by up-regulation of autophagy via ...

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Genipin alleviates vascular hyperpermeability following hemorrhagic shock by up-regulation of SIRT3/autophagy

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