Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury

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成果类型：

期刊论文

作者：

Gao, Yuan;Wang, Tao;Cheng, Ying;Wu, Yumin;Zhu, Luwen;...

通讯作者：

Luo, C.;Wang, F.;Tao, L.

作者机构：

[Luo, Chengliang; Cheng, Ying; Wang, Zufeng; Cai, Luwei; Wang, Ying; Li, Jing; Wang, Tao; Gao, Cheng; Wu, Yumin; Gu, Zhiya; Zhang, Yidan; Tao, Luyang] Soochow Univ, Sch Basic Med & Biol Sci, Dept Forens Med, Suzhou 215123, Peoples R China.

[Wu, Yimin; Zhu, Luwen; Wu, Youzhuang] Wenzhou Med Univ, Dept Forens Sci, Wenzhou 325035, Zhejiang, Peoples R China.

[Li, Lili] Soochow Univ, Childrens Hosp, Dept Child & Adolescent Healthcare, Suzhou 215021, Jiangsu, Peoples R China.

[Li, Qianqian] Wannan Med Coll, Sch Forens Med, Wuhu 241002, Anhui, Peoples R China.

[Wang, Fudi] Zhejiang Univ, Affiliated Hosp 2, Sch Publ Hlth, State Key Lab Expt Hematol,Sch Med, Hangzhou 310058, Peoples R China.

通讯机构：

[Tao, L.; Luo, C.] D

[Wang, F.] T

Department of Forensic Medicine, School of Basic Medicine and Biological Sciences, Soochow University, Suzhou, 215123, China

语种：

英文

关键词：

Ferritin H;Ferroptosis;Interleukin-33;MT1/2;Melatonin;Neuroinflammation;Traumatic brain injury

期刊：

Free Radical Biology and Medicine

ISSN：

0891-5849

年：

2023

卷：

199

页码：

97-112

DOI：

10.1016/j.freeradbiomed.2023.02.014

基金类别：

This work was supported by the National Natural Science Foundation of China ( 82101972 , 81971800 , 81971163 , 82271409 , 82072110 , 82001382 , 81530062 , and 31930057 ), Jiangsu Provincial Natural Science Foundation of China ( SBK2020040785 ), China Postdoctoral Science Foundation ( 2020M681723 ), National Key Research and Development Program of China ( 2018YFA0507802 ), a project of invigorating healthcare through science, technology, and education (KJXW2019018), a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) .

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本校为其他机构

院系归属：

公共卫生学院

摘要：

Although traumatic brain injury (TBI) is a common cause of death and disability worldwide, there is currently a lack of effective therapeutic drugs and targets. To reveal the complex pathophysiologic mechanisms of TBI, we performed transcriptome analysis of the mouse cerebral cortex and immunohistochemical analysis of human cerebral tissues. The genes Mt1, Mt2, Il33, and Fth1 were upregulated post-TBI and enriched in pathways associated with the inflammatory response, oxidative phosphorylation, and ferroptosis. As an agonist of MT1/2, melatonin (MLT) confers anti-oxidant, anti-inflammatory, an...

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Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury

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