Tailoring a traditional Chinese medicine prescription for complex diseases: A novel multi-targets-directed gradient weighting strategy

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成果类型：

期刊论文

作者：

Yu, Zhe;Li, Teng;Zheng, Zhi;Yang, Xiya;Guo, Xin;...

通讯作者：

Tang, Tao;Hu, E

作者机构：

[Zhu, Lin; Luo, Jiekun; Yang, Xueping; Yu, Zhe; Zhang, Xindi; Jiang, Haoying; Wang, Yang; Yang, Xiya; Yang, Bo; Guo, Xin; Li, Teng] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Dept Integrated Tradit Chinese & Western Med, Changsha 410008, Peoples R China.

[Zheng, Zhi] Cent South Univ, Xiangya Hosp, Jiangxi Natl Reg Ctr Neurol Dis, Dept Neurol, Nanchang 330038, Peoples R China.

[Zheng, Zhi] Jiangxi Prov Peoples Hosp, Nanchang Med Coll, Affiliated Hosp 1, Nanchang 330038, Peoples R China.

[Guo, Xin] Univ South China, Affiliated Hosp 1, Childrens Med Ctr, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Hu, En; Tang, Tao; Hu, E] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Natl Reg Ctr Neurol Dis,Dept Integrated Tradit Chi, Nanchang 330038, Peoples R China.

通讯机构：

[Tang, T; Hu, E ] C

Cent South Univ, Xiangya Hosp, Inst Integrat Med, Natl Reg Ctr Neurol Dis,Dept Integrated Tradit Chi, Nanchang 330038, Peoples R China.

语种：

英文

关键词：

Traditional Chinese medicine;Prescription formulation;Gradient weighting strategy;Multiple targets;Intracerebral hemorrhage

期刊：

药物分析学报(英文)

ISSN：

2095-1779

年：

2025

卷：

期：

页码：

101199

DOI：

10.1016/j.jpha.2025.101199

基金类别：

Key Research and Development Program of Hunan Province of China [2024M753698]; Natural Science Foundation of Hunan Province, China [2023SK2021, 2022SK2015]; Hunan Traditional Chinese Medicine Scientific Research Program, China [2024JJ6632, 2022JJ40853, 2021JJ31117]; Fundamental Research Funds for the Central Universities of Central South University, China [B2024113, B2024114, 2021032]; [1053320232786]

机构署名：

本校为其他机构

摘要：

Traditional Chinese medicine (TCM) exerts integrative effects on complex diseases owing the characteristics of multiple components with multiple targets. However, the syndrome-based system of diagnosis and treatment in TCM can easily lead to bias because of varying medication preferences among physicians, which has been a major challenge in the global acceptance and application of TCM. Therefore, a standardized TCM prescription system needs to be explored to promote its clinical application. In this study, we first developed a gradient weighted disease-target-herbal ingredient-herb network to ...

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Tailoring a traditional Chinese medicine prescription for complex diseases: A novel multi-targets-directed gradient weighting strategy

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