Epstein-Barr virus-encoded MIR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103

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成果类型：

期刊论文

作者：

He, Baoyu;Li, Weiming;Wu, Yingfen;Wei, Fang;Gong, Zhaojian;...

通讯作者：

Xiong, Wei;Zeng, Zhaoyang

作者机构：

[Li, Xiaoling; Ma, Jian; He, Baoyu; Wang, Yumin; Zeng, Zhaoyang; Guo, Can; Li, Yong; Zhou, Ming; Xiong, W; Xiong, Wei; Xiang, Bo; Li, Guiyuan] Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Carcinogenesis, Xiangya Rd, Changsha, Hunan, Peoples R China.

[Li, Weiming; Wei, Fang; Gong, Zhaojian; Li, Xiaoling; Ma, Jian; He, Baoyu; Zeng, Zhaoyang; Guo, Can; Li, Yong; Zhou, Ming; Xiong, Wei; Bo, Hao; Xiang, Bo; Wu, Yingfen; Li, Guiyuan] Cent S Univ, Key Lab Carcinogenesis & Canc Invas, Chinese Minist Hlth, Canc Res Inst, Changsha, Hunan, Peoples R China.

[Zeng, Zhaoyang; Zhou, Ming; Li, Xiayu] Cent S Univ, Hunan Key Lab Nonresolving Inflammat & Canc, Dis Genome Res Ctr, Xiangya Hosp 3, Changsha, Hunan, Peoples R China.

[Li, Xiaoling; Ma, Jian; Xiong, Wei; Liao, Qianjin; Chen, Pan] Cent S Univ, Hunan Key Lab Translat Radiat Oncol, Hunan Canc Hosp, Changsha, Hunan, Peoples R China.

[Li, Xiaoling; Ma, Jian; Xiong, Wei; Liao, Qianjin; Chen, Pan] Cent S Univ, Affiliated Canc Hosp, Xiangya Sch Med, Changsha, Hunan, Peoples R China.

通讯机构：

[Xiong, W; Zeng, ZY] C

Cent S Univ, Xiangya Hosp, Chinese Minist Hlth, Key Lab Carcinogenesis, Xiangya Rd, Changsha, Hunan, Peoples R China.

语种：

英文

期刊：

CELL DEATH & DISEASE

ISSN：

2041-4889

年：

2016

卷：

期：

页码：

e2353

DOI：

10.1038/cddis.2016.253

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372907,, 81301757, 81472531, 81402009, 81572787, 81672683, 81672993]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [14JJ1010, 2015JJ1022]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Epstein-Barr virus (EBV) infection is causatively related to a variety of human cancers, including nasopharyngeal carcinoma (NPC) and gastric cancer (GC). EBV encodes 44 mature miRNAs, a number of which have been proven to promote carcinogenesis by targeting host genes or self-viral genes. However, in this study, we found that an EBV-encoded microRNA, termed EBV-miR-BART6-3p, inhibited EBV-Associated cancer cell migration and invasion including NPC and GC by reversing the epithelial-mesenchymal transition (EMT) process. Using microarray analysi...

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Epstein-Barr virus-encoded MIR-BART6-3p inhibits cancer cell metastasis and invasion by targeting long non-coding RNA LOC553103

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