期刊论文

Geng, Bin

英文

Biochemical and Biophysical Research Communications

0006-291X

2009

380

1

153-159

10.1016/j.bbrc.2009.01.059

This work was supported by The Major State Basic Research Development Program of the People’s Republic of China (no. 2006CB503807) and the National Natural Science Foundation of China (NSFC: 30570766). We also thank Professor Guoheng Xu for technical support in adipocyte isolation and culture.

本校为第一机构

Recent data suggested that endogenous hydrogen sulfide (H2S) contributes to the pathogenesis of diabetes. Here, we identified that cystathionine gamma lyase (CSE) was expressed in adipose tissue in rats and endogenously generated H2S. The CSE/H2S system exists in both rat adipocytes and pre-adipocytes. This system was up-regulated with aging, although a high level of glucose down-regulated the system in a concentration- and time-dependent manner. H2S inhibited the basal and insulin-stimulated glucose uptake of mature adipocytes, whereas adminis...