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Peripheral administration of the NAT10 inhibitor Remodelin prevents against Lipopolysaccharide induced depression in male mice

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成果类型:
期刊论文
作者:
Xu, Xiao Fan;Zhang, Ao Mei;Hu, Tao;Yang, Jingwen;Wang, Meng;...
通讯作者:
Xu, Yang;Cao, WY;Xu, Y
作者机构:
[Xu, Yang; Hu, Tao; Zhang, Ao Mei; Xu, Y; Xu, Xiao Fan; Cao, WY; Wang, Meng; Yang, Jingwen; Cao, Wen Yu] Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
[Xu, Xiao Fan] Liaocheng Peoples Hosp, Dept Neurosurg, Liaocheng 252000, Shandong, Peoples R China.
[Xu, Yang; Xu, Y] Univ South China, Inst Neurosci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Xu, Y; Xu, Y ; Cao, WY ] U
Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
Univ South China, Inst Neurosci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Depression;Hippocampus;Inflammation;Microglia;NAT10
期刊:
European Journal of Pharmacology
ISSN:
0014-2999
年:
2025
卷:
1003
页码:
177884
基金类别:
CRediT authorship contribution statement Wenyu Cao: Writing – review & editing, Writing – original draft, Supervision, Resources, Investigation, acquisition, Conceptualization. Yang Xu: Writing – review & editing, Writing – original draft, Supervision, Resources, Investigation, acquisition. Meng Wang: Validation, Methodology. Jingwen Yang: Validation, Methodology. Tao Hu: Project administration, Methodology. Aomei Zhang: Project administration, Methodology. Xiaofan Xu: Writing – original draft, Project administration,
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
N-acetyltransferase 10 (NAT10) is a key enzyme for N4-acetylcytidine (ac4C) modification of mRNA, but its functions in the central nervous system remain unclear. In this study, we explored the spatial localization of NAT10 and observed the alterations of it in the brain of Lipopolysaccharide (LPS) treated mice. Meanwhile, we observed the changes of depression-like behaviors after blocking NAT10 systematically with its inhibitor Remodelin or knockdown hippocampal NAT10 in LPS treated mice and explored its potential mechanism. After having showed the NAT10 is highly expressed in the mouse brain ...

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