期刊论文

Xu, Yang;Cao, WY;Xu, Y

英文

European Journal of Pharmacology

0014-2999

2025

1003

177884

10.1016/j.ejphar.2025.177884

CRediT authorship contribution statement Xiao Fan Xu: Writing – original draft, Project administration, Methodology. Ao mei Zhang: Project administration, Methodology. Tao Hu: Project administration, Methodology. Jingwen Yang: Validation, Methodology. Meng Wang: Validation, Methodology. Yang Xu: Writing – review & editing, Writing – original draft, Supervision, Resources, Investigation, acquisition. Wen Yu Cao: Writing – review & editing, Writing – original draft, Supervision, Resources, Investigation, acquisition,

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N-acetyltransferase 10 (NAT10) is a key enzyme for N4-acetylcytidine (ac4C) modification of mRNA, but its functions in the central nervous system remain unclear. In this study, we explored the spatial localization of NAT10 and observed the alterations of it in the brain of l ipopolysaccharide (LPS) treated mice. Meanwhile, we observed the changes of depression-like behaviors after blocking NAT10 systematically with its inhibitor Remodelin or knockdown hippocampal NAT10 in LPS treated mice and explored its potential mechanism. After having showed the NAT10 is highly expressed in the mouse brain...