期刊论文

Comparison of volumetric modulated arc therapy stereotactic radiosurgery plans of multiple brain metastases

中文

中国医学物理学杂志

1005-202X

2021

38

12

1482-1486

10.3969/j.issn.1005-202X.2021.12.006

国家自然科学基金（11704108）；

本校为其他机构

目的:通过调整容积旋转调强(VMAT)计划等中心数目及其共面条件,研究其在多发性脑转移瘤治疗中的剂量学特征,为其临床应用提供指导。方法:收集2019年在湖北省肿瘤医院治疗的多发性脑转移瘤1例,分别设计1个等中心4个非共面弧、5个等中心5个共面弧以及5个等中心5个非共面弧计划,要求处方剂量(24 Gy/3次)覆盖95%靶体积。计划评价参数包括靶区适形度指数、梯度指数、脑部放射坏死指标(V_(12))和低剂量区(V_(5))体积覆盖率。结果:VMAT单等中心非共面弧计划对比多等中心计划有着更好的靶区适形度和更小的V_(12),且在小体积肿瘤的治疗中有着更好的剂量跌落。结论:VMAT单等中心非共面弧计划比多等中心共面...

Objective To study the dosimetric characteristics of volumetric modulated arc therapy (VMAT) in the treatment of multiple brain metastases by adjusting the number of isocenters with coplanar arcs or not.Methods A case of multiple brain metastases treated in Hubei Cancer Hospital in 2019 was selected in the study.Three kinds of plans,namely single-isocenter with 4 non-coplanar arcs,5-isocenter with 5 coplanar arcs and 5-isocenter with 5 non-coplanar arcs,were designed separately.The prescription dose (24 Gy/3 fractions) was required to cover 95% of the target volume.The evaluation parameters in...