期刊论文

中文

中国医学物理学杂志

1005-202X

2018

35

1

36-40

10.3969/j.issn.1005-202X.2018.01.008

本校为第一机构

目的:评估基于危及器官分区约束的等效均匀剂量优化在直肠癌容积调强放疗中的剂量学和生物学优势。方法:随机选取临床批准的经过剂量-体积优化的直肠癌容积调强放疗计划10例(PHY计划)。以PHY计划为基础,分别根据小肠,膀胱与靶区的位置关系,将危及器官进行分区并根据组织特性参数(a值)对剂量热点敏感性的不同,给予不同的a值进行等效均匀剂量优化(EUD计划)。根据a值越大对剂量热点越敏感这一特点,靶区与危及器官重叠部分的剂量相对其它区域来说较高,热点出现概率较大,取较大的a值进行等效均匀剂量优化(a=10)。重叠部分外扩9 mm且与小肠和膀胱相交区域的剂量热点出现概率相对重叠区域较低,a值取8和...

Objective To evaluate the dosimetric and biological advantages of equivalent uniformdose optimization based on organsat- risk (OAR) partition constraint in volumetric modulated arc therapy (VMAT) for rectal cancer. Methods With dose-volume constraints, 10 VMAT plans for rectal cancer which were approved in clinic were selected (PHY plans). Based on the PHY plans, we performed the OAR partition according to the position relationships among the small intestine, the bladder and target areas, and carried out the equivalent uniform dose (EUD) optimization by giving different specific-tissues parame...