期刊论文

中文

中国医学物理学杂志

1005-202X

2018

35

2

171-175

10.3969/j.issn.1005-202X.2018.02.010

本校为第一机构

目的:比较基于广义等效均匀剂量(gEUD)优化的容积旋转调强和固定野调强技术直肠癌放疗的生物学参数和剂量学特点,为临床选择提供一定依据。方法:选取10名经过医生勾画靶区的直肠癌患者,对每位患者分别设计5野调强计划(5FIMRT)、7野调强计划(7FIMRT)和容积旋转调强计划(RapidArc),处方剂量为50 Gy/25 F。比较3组计划的平均剂量体积直方图和机器跳数,靶区适形度、均匀性,危及器官的正常组织并发症概率(NTCP)及靶区和危及器官的gEUD和物理剂量。结果:3组计划的靶区剂量均能达到临床要求。在适形度与均匀性上,RapidArc优于5 FIMRT和7 FIMRT(P0.05),且均优于5FIMRT(P

Objective To compare the biological and dosimetric differences of volumetric modulated arc therapy (RapidArc) and fixed-field intensity-modulated radiotherapy (IMRT) based on generalized equivalent uniform dose (gEUD) optimization for rectal cancer and provide some reference for clinical decision. Methods Ten patients with rectal cancer were selected, and three kinds of plans were designed for each patient, namely five-field IMRT (5FIMRT), seven-field IMRT (7FIMRT) and RapidArc plans, with the same prescription dose of 50 Gy/25 F for planning target volume (PTV). Finally, we applied paired t t...