期刊论文

Influence of anatomical changes and setup error on radiotherapy dosimetry in patients with nasopharyngeal carcinoma

中文

中国医学物理学杂志

1005-202X

2017

34

4

348-354

10.3969/j.issn.1005-202X.2017.04.006

浙江省自然科学基金

本校为第一机构

目的:研究鼻咽癌患者放疗过程中,摆位误差和解剖结构的变化所引起的危及器官的剂量学变化,从而为下一步的自适应放疗提供一定依据。方法:随机选取10例进行调强放射治疗的鼻咽癌患者,在放射治疗过程中选取6次进行千伏级锥形束CT(kV-CBCT)在线引导体位校正,统计整个疗程的摆位误差数据。将每次获得的CBCT图像与CT图像进行中心点的图像配准,并将移位数据带入其中,得到患者治疗时的真实位置,通过模拟计算在保持原始照射条件不变的情况下,在CBCT图像上重新计算,重新勾画靶区及危及器官,然后通过形变配准进行剂量的叠加,比较腮腺、脊髓、脑干等危及器官的剂量学变化。结果:(1)10例鼻咽癌患者在放射治疗...

Objective To study the dosimetric changes in the organs-at-risk (OAR) caused by setup errors and anatomical changes in patients receiving radiotherapy for nasopharyngeal carcinoma (NPC) and provide evidence for further adaptive radiotherapy. Methods Ten NPC patients undergoing intensity-modulated radiotherapy (IMRT) were selected randomly for analysis. In 6 sessions of IMRT, kV-cone beam CT (CBCT)-guided position correction was performed and the set-up errors of the entire treatment course of treatment were recorded. After registration between ...