期刊论文

中文

中国医学物理学杂志

1005-202X

2016

33

2

190-194

10.3969/j.issn.1005-202X.2016.02.017

江西省卫生厅科技计划项目

本校为第一机构

目的:探讨生物等效均匀剂量优化算法在调强放疗中对正常组织的保护作用,为临床调强计划设计优化提供更好的经验。方法:随机抽取鼻咽癌、食管癌和直肠癌各20例患者作为研究对象,分别对患者设计两组治疗计划进行调强优化。1组对危及器官增设等效均匀剂量(Equivalent Uniform Dose, EUD)生物优化(Plan-EUD)条件限制,另一组进行常规物理参数优化(Plan-noEUD)。采用统计学方法对两组计划正常组织剂量限制作用进行比较。结果:Plan-EUD组优化后腮腺平均剂量为2737 cGy,平均V_(30)为39.5%,平均并发症概率(NTCP)为0.29,Plan-noEUD组优化后相应值分别为3087cGy、46.2%、0.38。EUD优化平均剂量下降350 cGy,...

Objective Toprovide a better experience for theoptimization of intensity modulated radiotherapy (IMRT) plan design by investigating the protective effect of biological equivalent uniform dose optimization algorithm on the normal tissue in IMRT. Methods Patients respectively with nasopharyngeal cancer, esophageal cancer and rectal cancer were randomly selected, 20 patients of each. Two plans were respectively designed for each patient to undergo the intensity modulated optimization. The condition limit of biological equivalent uniform dose (EUD) optimization for organs at risk was considered in...