NO-1886 Up-regulates Niemann-Pick C1 protein (NPC1) expression through liver X receptor α signaling pathway in THP-1 macrophage-derived foam cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ma, Xin;Hu, Yan-Wei;Mo, Zhong-Cheng;Li, Xiao-Xu;Liu, Xie-Hong;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Tang, Chao-Ke; Li, Xiao-Xu; Hu, Yan-Wei; Ma, Xin; Liu, Xie-Hong; Yin, Wei-Dong; Mo, Zhong-Cheng; Xiao, Ji] Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

[Ma, Xin] Univ S China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Liao, Duan-Fang] Univ S China, Inst Pharm & Pharmacol, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Chao-Ke] U

Univ S China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Atherosclerosis;Cholesterol;LXR α;NO-1886;NPC1

期刊：

Cardiovascular Drugs and Therapy

ISSN：

0920-3206

年：

2009

卷：

期：

页码：

199-206

DOI：

10.1007/s10557-009-6165-8

基金类别：

Acknowledgment The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China (30470720), Post-doctor Sciences Foundation of China (2005037157), Hunan Provincial Natural Sciences Foundation of China (06jj5058) and The National Major Basic Research Program of China (973 Program) (grant no. 2006CB503808).

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

Background: The Niemann-Pick C1 (NPC1) protein regulates the transport of cholesterol from late endosomes/lysosomes to other compartments responsible for maintaining intracellular cholesterol homeostasis. Liver X receptors (LXRs) operate as cholesterol sensors which may protect from cholesterol overload by increasing the amount of free cholesterol in the plasma membrane through inducing NPC1 expression. NO-1886 has been proven to be highly effective at increasing liver X receptor α expression and promoting cellular cholesterol efflux. In this ...

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NO-1886 Up-regulates Niemann-Pick C1 protein (NPC1) expression through liver X receptor α signaling pathway in THP-1 macrophage-derived foam cells

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