Wnt/β-catenin signalling mediates cardiac hypertrophy in type 4 cardiorenal syndrome

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成果类型：

期刊论文

作者：

Zhao, Yue;Lei, Yanping;Li, Yueyan;Zhang, Jingjing;Tang, Huifang*

通讯作者：

Tang, Huifang

作者机构：

[Zhang, Jingjing; Tang, Huifang; Zhao, Yue; Li, Yueyan] Univ South China, Affiliated Hosp 1, Dept Cardiol, Chuanshan Rd 69, Hengyang, Hunan, Peoples R China.

[Lei, Yanping] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov,Hengyang Med Co, Hunan Int Sci & Technol Cooperat Base Arterioscle, Hengyang, Hunan, Peoples R China.

通讯机构：

[Tang, Huifang] U

Univ South China, Affiliated Hosp 1, Dept Cardiol, Chuanshan Rd 69, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

alpha actin;beta catenin;fibronectin;n benzyl 1,2,3,4,8,9 hexahydro 6 (4 hydroxybenzyl) 8 (1 naphthylmethyl) 4,7 dioxo 2h pyrazino[1,2 a]pyrimidine 1(6h) carboxamide;podocalyxin;tumor necrosis factor;animal cell;animal experiment;animal tissue;Article;cardiac muscle cell;cardiorenal syndrome;cardiorenal syndrome type 4;circulation;controlled study;disease exacerbation;heart ventricle hypertrophy;in vitro study;in vivo study;kidney injury;molecular interaction;nephrectomy;nonhuman;pathophysiology;priority journal;protein blood level;rat;Sprague Dawley rat;Wnt signaling

期刊：

Nephrology

ISSN：

1320-5358

年：

2021

卷：

期：

页码：

549-560

DOI：

10.1111/nep.13848

基金类别：

This work was supported by Science Foundation of the Health Care Commission in Hunan Province of China (B2019122). Some technology support of methods in this study was provided by State Key Laboratory of Organ Failure Research, National Clinical Research Center of Kidney Disease, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China. The authors sincerely thank for free contribution of them, including Liu youhua, Zhou lili.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

AbstractAimCardiorenal syndrome type 4 (CRS4) is characterized by the condition that chronic kidney disease (CKD) causes sustainable injury to heart. This study focuses on exploring the mechanism underlying CRS4 and potential treatment for CRS4.MethodsIn the present study, Sprague Dawley (SD) rats were subjected to 5/6 subtotal nephrectomy (5/6NX) for generating animal model of CKD. Cardiac hypertrophy, kidney injury, Wnt/β‐catenin signalling and serum TNF‐α were tested at eighth week after 5/6NX.ResultsCardiac hypertrophy and kidney injury...

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Wnt/β-catenin signalling mediates cardiac hypertrophy in type 4 cardiorenal syndrome

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