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Vimentin Is an Attachment Receptor for Mycoplasma pneumoniae P1 Protein

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成果类型:
期刊论文
作者:
Peng, Kailan;Liao, Yating;Li, Xia;Zeng, Dongdong;Ye, Youyuan;...
通讯作者:
Yanhua Zeng
作者机构:
[Liao, Yating; Zeng, Zhuo; Ye, Youyuan; Peng, Kailan; Zeng, Yanhua; Li, Xia; Chen, Li] Univ South China, Inst Pathogen Biol, Hengyang Med Coll, Basic Med Sch,Hunan Prov Key Lab Special Pathogens, Hengyang, Hunan, Peoples R China.
[Zeng, Dongdong] Univ South China, Affiliated Hosp 3, Dept Cardiocascular Med, Hengyang, Hunan, Peoples R China.
通讯机构:
[Yanhua Zeng] I
Institute of Pathogenic Biology, Basic Medical School, Hengyang Medical College, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, Hunan Province, People’s Republic of China
语种:
英文
关键词:
Mycoplasma pneumoniae;P1 protein;vimentin;BEAS-2B;receptor
期刊:
MICROBIOLOGY SPECTRUM
ISSN:
2165-0497
年:
2023
卷:
11
期:
2
页码:
e0448922
基金类别:
Natural Science Foundation of Hunan Province [2021JJ30587]; Key Project of Health Commission of Hunan Province [202101061310]
机构署名:
本校为第一机构
院系归属:
医学院
摘要:
Mycoplasma pneumoniae is the most common pathogen causing respiratory tract infection, and the P1 protein on its adhesion organelle plays a crucial role during the pathogenic process. A variety of experiments, including enzyme-linked immunosorbent assay (ELISA), coimmunoprecipitation, adhesion, and adhesion inhibition assay, have demonstrated that the M. pneumoniae P1 protein can interact with vimentin, that the adhesion of M. pneumoniae and recombinant P1 protein to BEAS-2B cells was affected by the expression level of vimentin. Mycoplasma pneumoniae is the most common pathogen causing respir...

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