Proteomic analysis of the stroma-related proteins in nasopharyngeal carcinoma and normal nasopharyngeal epithelial tissues

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成果类型：

期刊论文

作者：

Li, Mei-xiang;Xiao, Zhi-qiang;Chen, Yong-heng;Peng, Fang;Li, Cui;...

通讯作者：

Chen, Zhu-chu

作者机构：

[Yao, Hui-xin; Li, Dan-Juan; Li, Cui; Xiao, Zhi-qiang; Li, Mao-yu; Duan, Chao-jun; Peng, Fang; Zhang, Peng-fei; Li, Mei-xiang; Chen, Zhu-chu] Cent S Univ, Key Lab Canc Prote, Chinese Minist Hlth, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.

[Yao, Hui-xin; Li, Feng; Li, Mei-xiang; Chen, Zhu-chu] Cent S Univ, Canc Res Inst, Xiangya Sch Med, Changsha 410078, Hunan, Peoples R China.

[Li, Mei-xiang] Univ S China, Dept Histol & Embryol, Hengyang 421001, Hunan, Peoples R China.

[Chen, Yong-heng] Univ So Calif, Los Angeles, CA USA.

[Chen, Zhu-chu] Cent S Univ, Key Lab Canc Prote, Chinese Minist Hlth, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Chen, Zhu-chu] C

Cent S Univ, Key Lab Canc Prote, Chinese Minist Hlth, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Nasopharyngeal carcinoma;Stroma;Laser capture microdissection;Two-dimensional gel electrophoresis;Mass spectrometry

期刊：

Medical Oncology

ISSN：

1357-0560

年：

2010

卷：

期：

页码：

134-144

DOI：

10.1007/s12032-009-9184-1

基金类别：

Science and Technology Committee of Hunan Province, China [04XK1001, 06SK2004]; National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30500558, 30670990]; New Century Excellent Talents in University (NCET)Program for New Century Excellent Talents in University (NCET); National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30670990, 30871189]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The stroma surrounding cancer cell population is increasingly recognized as playing an important role in cancer proliferation, invasion, and metastasis. To identify the stromal proteins involved in nasopharyngeal carcinoma (NPC) carcinogenesis, differences in protein expression of the stroma from NPC and normal nasopharyngeal epithelium tissues (NNET) were assessed using a comparative proteomic approach combined with laser capture microdissection (LCM). LCM was performed to purify stromal cells from NPC and NNET, respectively. Proteins between the pooled microdissected tumor and normal stroma ...

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Proteomic analysis of the stroma-related proteins in nasopharyngeal carcinoma and normal nasopharyngeal epithelial tissues

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