期刊论文

Li, JJ

英文

Experimental Biology and Medicine

1535-3702

2023

248

12

1085-1094

10.1177/15353702231167940

We thank Prof. Chao-Nan Qian from Sun Yat-Sen University Cancer Center for providing the N-cadherein, β-catenin, and fibronectin antibodies. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported partially by the Natural Science Foundation of Hunan Province, China (2020JJ4539 and 2021JJ30610); and the Key Guiding Project of Hunan Provincial Health Commission (202104101985); the Science and Technology Innovation Project of Hengyang City (202150064015); the University of South China Teaching Reform Research Project (2020YB-XJG127); and the National High Technology Research and Development Program of China (863 Program) (2012AA02A206).

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Cytoskeleton-associated protein 4 (CKAP4) acts as a key transmembrane protein that connects the endoplasmic reticulum (ER) to microtubule dynamics. Researchers have not examined the roles of CKAP4 in nasopharyngeal carcinoma (NPC). The study aimed at evaluating the prognostic value and metastasis-regulating effect of CKAP4 in NPC. CKAP4 protein could be observed in 86.36% of 557 NPC specimens but not in normal nasopharyngeal epithelial tissue. According to immunoblot assays, NPC cell lines presented high CKAP4 expression relative to NP69 immort...