期刊论文

Effects of simvastatin on pulmonary fibrosis and endothelial - mesenchymal transition in the pulmonary fibrosis tissue of rats

中文

中国应用生理学杂志

1000-6834

2021

37

05

454-459

10.12047/j.cjap.6120.2021.068

湖南省教育厅（18C0453）；

本校为第一机构

目的:观察辛伐他汀对大鼠肺纤维化及其内皮间质变(EnMT)过程中VE-钙粘素(VE-cad) 、波形蛋白(VIM) 、α-平滑肌蛋白(α-SMA)表达的影响。方法:健康雄性SD大鼠60只,随机分为对照组(A组) 、造模组(B组) 、辛伐他汀5 mg治疗组(C组) 、辛伐他汀10 mg治疗组(D组),每组各15只。博来霉素(BLM)按5 mg /kg剂量一次性气管内灌注复制博莱霉素致大鼠肺纤维化模型,从造模第1日起C、D组每天分别胃内灌注辛伐他汀混悬液5 mg /(kg·d)及辛伐他汀混悬液10 mg /(kg·d),A组和B组每天胃内灌注等体积生理盐水10 ml /(kg·d) 。于造模第7、14和28日随机处死各组大鼠5只。Masson染色观察大鼠肺组织形态变化;碱性水解法...

Objective: To investigate the effects of simvastatin (SIM) on pulmonary fibrosis and the expression of VE-cadherin (VE-cad), vimentin(VIM) and alpha-smooth muscle actin(α-SMA) in the pulmonary fibrosis tissue of rats. Methods: Sixty healthy male SD rats were randomly divided into control group(group A),bleomycin group(group B),5 mg SIM group (group C) and 10 mg SIM group (group D), 15 rats in each group. The model of rat pulmonary fibrosis was established by itraperitoneal injection of bleomycin(5 mg /kg). Since the first day of modeling,the r...