LncRNA ZEB1-AS1/miR-1224-5p / MAP4K4 axis regulates mitochondria-mediated HeLa cell apoptosis in persistent Chlamydia trachomatis infection

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Luo, Fangzhen;Wen, Yating;Zhao, Lanhua;Su, Shengmei;Lei, Wenbo;...

通讯作者：

Qiulin Huang<&wdkj&>Zhongyu Li

作者机构：

[Luo, Fangzhen; Li, Zhongyu; Su, Shengmei; Lei, Wenbo; Zhao, Lanhua; Chen, Chaoqun; Chen, Lili; Wen, Yating] Univ South China, Hengyang Med Sch, Inst Pathogen Biol, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang, Peoples R China.

[Luo, Fangzhen] Hunan Polytech Environm & Biol, Coll Med Technol, Hengyang, Peoples R China.

[Huang, Qiulin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Qiulin Huang] T

[Zhongyu Li] I

The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, P. R. China<&wdkj&>Institute of Pathogenic Biology, Hengyang Medical School, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang, P. R. China

语种：

英文

关键词：

Chlamydia trachomatis;MAP4K4;antiapoptosis;lncRNA ZEB1-AS1;miR-1224-5p;persistent infection

期刊：

Virulence

ISSN：

2150-5594

年：

2022

卷：

期：

页码：

444-457

DOI：

10.1080/21505594.2022.2044666

基金类别：

National Natural Science Foundation of China [32070189, 81772210]; Key Program of Hunan Provincial Department of Education [20A421]; Hunan Provincial Natural Science Foundation of China [2021JJ30594, 2021JJ60043]; Clinical Research Project of University of South China [USCKF201902K01]; Scientific Research Project of Hunan Provincial Health Commission [202201062549]; Excellent Plan Scientific Research Project of Hunan Polytechnic of Environment and Biology [PY2021-11]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Persistent infection of Chlamydia trachomatis is thought to be responsible for the debilitating sequelae of blinding trachoma and infertility. Inhibition of host cell apoptosis is a persistent C. trachomatis infection mechanism. ZEB1-AS1 is a long non-coding RNA (lncRNA), which was up-regulated in persistent C. trachomatis infection in our previous work. In this study, we investigated the role of ZEB1-AS1 in persistent infection and the potential mechanisms. The results showed that ZEB1-AS1 was involved in the regulation of apoptosis, and targeted silencing of ZEB1-AS1 could increase the apopt...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

LncRNA ZEB1-AS1/miR-1224-5p / MAP4K4 axis regulates mitochondria-mediated HeLa cell apoptosis in persistent Chlamydia trachomatis infection

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问