This study was supported by grants from the National Natural Science Foundation of China (Number: 801301495). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Background: The regulation of microglial function via mitochondrial homeostasis is important in the development of neuroinflammation. The underlying mechanism for this regulatory function remains unclear. In this study, we investigated the protective role of mitochonic acid 5 (MA-5) in microglial mitochondrial apoptosis following TNFα-induced inflammatory injury. Methods: TNFα was used to induce inflammatory injury in mouse microglial BV-2 cells with and without prior MA-5 treatment. Cellular apoptosis was assessed using the MTT and TUNEL ass...