MicroRNA-133a and microRNA-326 co-contribute to hepatocellular carcinoma 5-fluorouracil and cisplatin sensitivity by directly targeting B-cell lymphoma-extra large

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ma, Jin;Wang, Ting;Guo, Rui;Yang, Xiaoyan;Yin, Jie;...

通讯作者：

Lei, Xiaoyong

作者机构：

[Yang, Xiaoyan; Wang, Ting; Guo, Rui; Yin, Jie; Pan, Xia; Xiang, Qiong; Peng, Cuiying; Lei, Xiaoyong; Ma, Jin; Yu, Jia] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Hunan, Peoples R China.

[Zu, Xuyu] Univ South China, Affiliated Hosp 1, Inst Clin Med, Hengyang 421001, Hunan, Peoples R China.

[Tang, Huifang] Univ South China, Affiliated Hosp 1, Dept Cardiol, Hengyang 421001, Hunan, Peoples R China.

[Lei, Xiaoyong] Univ South China, Inst Pharm & Pharmacol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Lei, Xiaoyong] U

Univ South China, Inst Pharm & Pharmacol, 28 Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

microRNA;hepatocellular carcinoma;5-fluorouracil;B-cell lymphoma-extra large;cisplatin

期刊：

MOLECULAR MEDICINE REPORTS

ISSN：

1791-2997

年：

2015

卷：

期：

页码：

6235-6240

DOI：

10.3892/mmr.2015.4134

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372579, 30900625]; Science and Technology Department Projects of Hunan Province [2012FJ2016]; Science and Technology Development Project of Hengyang [2012KS13]; Hunan and Innovation Fund Project of Hunan Higher Education Institution [13K084]; Construction Projects of Provincial Key Disciplines

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Chemotherapy is one of the most common treatments used for hepatocellular carcinoma (HCC), which effectively improves outcome and reduces tumor recurrence. However, the drug resistance mechanisms involved in chemotherapy, which is the predominant challenge in HCC treatment, remain to be fully elucidated. Therefore, there is an urgent requirement for the identification of novel therapeutic strategies or drugs. MicroRNAs (miRs) have become an area of interest, and in the present study, the effects of miR133a and miR326 on HepG2 cells, and their function on Bcell lymphomaextra large (Bclxl) in He...

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MicroRNA-133a and microRNA-326 co-contribute to hepatocellular carcinoma 5-fluorouracil and cisplatin sensitivity by directly targeting B-cell lymphoma-extra large

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