Itaconate: an emerging determinant of inflammation in activated macrophages

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yu, Xiao-Hua;Zhang, Da-Wei;Zheng, Xi-Long;Tang, Chao-Ke*

通讯作者：

Tang, Chao-Ke

作者机构：

[Tang, Chao-Ke; Yu, Xiao-Hua] Univ South China, Inst Cardiovasc Dis, Key Lab Arteriosclerol Hunan Prov,Med Res Expt Ct, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Da-Wei] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2S2, Canada.

[Zhang, Da-Wei] Univ Alberta, Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2S2, Canada.

[Zheng, Xi-Long] Univ Calgary, Libin Cardiovasc Inst Alberta, Cumming Sch Med, Hlth Sci Ctr,Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

[Tang, Chao-Ke] Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

inflammation;IRG1;itaconate;IκBζ;Nrf2;SDH

期刊：

IMMUNOLOGY AND CELL BIOLOGY

ISSN：

0818-9641

年：

2019

卷：

期：

页码：

134-141

DOI：

10.1111/imcb.12218

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770461]; Hunan Provincial Innovation Foundation for Postgraduate

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Macrophages play a central role in innate immunity as the first line of defense against pathogen infection. Upon exposure to inflammatory stimuli, macrophages rapidly respond and subsequently undergo metabolic reprogramming to substantially produce cellular metabolites such as itaconate. As a derivate of the tricarboxylic acid cycle, itaconate is derived from the decarboxylation of cis-aconitate mediated by immunoresponsive gene 1 in the mitochondrial matrix. It is well known that itaconate has a direct antimicrobial effect by inhibiting isocitrate lyase. Strikingly, two recent studies publish...

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Itaconate: an emerging determinant of inflammation in activated macrophages

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