Mycoplasma genitalium lipoproteins inhibit tumour necrosis factor α-induced apoptosis in HeLa cells

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成果类型：

期刊论文

作者：

Zuo, Lingling;Sun, Hedong;Yu, Minjun;You, Xiaoxing;Zeng, Yanhua;...

通讯作者：

Wu, Yimou

作者机构：

[Zuo, Lingling] Univ South China, Affiliated Hosp 2, Dept Transfus Med, Hengyang, Peoples R China.

[Wu, Yimou; Zuo, Lingling; Yu, Minjun; You, Xiaoxing; Zeng, Yanhua] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol, Med Coll, Hengyang, Peoples R China.

[Wu, Yimou; Zuo, Lingling; Yu, Minjun; You, Xiaoxing; Zeng, Yanhua] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

[Sun, Hedong] Univ South China, Dept Neurol, Affiliated Hosp 2, Hengyang, Peoples R China.

通讯机构：

[Wu, Yimou] U

[Wu, Yimou] H

Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol, Med Coll, Hengyang, Peoples R China.

Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China.

语种：

英文

关键词：

Mycoplasma genitalium lipoproteins;LAMPs;tumour necrosis factor alpha (TNF-alpha);apoptosis;HeLa cells

期刊：

Biotechnology & Biotechnological Equipment

ISSN：

1310-2818

年：

2018

卷：

期：

页码：

1590-1597

DOI：

10.1080/13102818.2018.1523688

基金类别：

This work was supported by the Foundation of Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation under grant number 2014-5, the Construct Program of the Key Discipline in Hunan Province under grant number 2011-75 and the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study under grant number 2015-351.

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

This aim of this study was to investigate the effects of Mycoplasma genitalium lipoproteins on the tumour necrosis factor α (TNF-α)-induced apoptosis in HeLa cells. We separated the M. genitalium lipid-associated membrane proteins (LAMPs) from M. genitalium and used them to treat HeLa cells. Apoptosis was induced by TNF-α treatment. Cell cycle and apoptosis were detected by flow cytometry. Pro-inflammatory cytokine contents were determined by enzyme-linked immunosorbent assay (ELISA). Mitochondrial membrane potential and caspase-3 protease a...

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Mycoplasma genitalium lipoproteins inhibit tumour necrosis factor α-induced apoptosis in HeLa cells

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