Amelioration of scopolamine-induced learning and memory impairment by the TRPV4 inhibitor HC067047 in ICR mice

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Deng, Yingcheng;Li, Wei;Niu, Lei;Luo, Xianglin;Li, Jing;...

通讯作者：

Wan, Wei

作者机构：

[Wan, Wei; Deng, Yingcheng; Luo, Xianglin; Li, Wei; Li, Jing; Niu, Lei] Univ South China, Hengyang Med Coll, Clin Anat & Reprod Med Applicat Inst, Hengyang 421001, Hunan, Peoples R China.

[He, Jie; Zhang, Yuan] Univ South China, Hengyang Med Coll, Dept Pathol, Hengyang 421001, Hunan, Peoples R China.

[Niu, Lei] Liuyang Tradit Chinese Med Hosp, Liuyang 410300, Hunan, Peoples R China.

[Wan, Wei] Hainan Med Univ, China Key Lab Brain Sci Res & Transformat Trop En, Haikou 571199, Hainan, Peoples R China.

[Liu, Hong] 922 Hosp PLA Joint Logist Support Force, Dept Orthoped, Kunming, Yunnan, Peoples R China.

通讯机构：

[Wan, Wei] U

Univ South China, Hengyang Med Coll, Clin Anat & Reprod Med Applicat Inst, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

*Alzheimer’s disease;*Cognitive dysfunction;*HC067047;*Scopolamine;*TRPV4

期刊：

Neuroscience Letters

ISSN：

0304-3940

年：

2022

卷：

767

页码：

136209

DOI：

10.1016/j.neulet.2021.136209

基金类别：

Hunan Provincial Education Department Foundation of China [2019JJ40257]; Undergraduate Innovation and Entrepreneurship Training Program of Hunan Province [S202010555252]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Alzheimer's disease (AD) is one of the most common causes of neurodegenerative diseases in the elderly. Cholinergic dysfunction is one of the pathological hallmarks of AD and leads to learning and memory impairment. Transient receptor potential vanilloid 4 (TRPV4), a nonselective cation channel, is involved in learning and memory functions. HC067047, a TRPV4 specific inhibitor, has been reported to protect neurons against cerebral ischemic injury and amyloid-β-(Aβ) 40-induced hippocampal cell death. However, whether HC067047 could improve sco...

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Amelioration of scopolamine-induced learning and memory impairment by the TRPV4 inhibitor HC067047 in ICR mice

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