Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

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成果类型：

期刊论文

作者：

Goh, MeeiChyn;Du, Meng;Peng, Wang Rui;Saw, Phei Er;Chen, Zhiyi

通讯作者：

Chen, ZY;Saw, PE

作者机构：

[Peng, Wang Rui; Du, Meng; Chen, Zhiyi; Goh, MeeiChyn] Univ South China, Inst Med Imaging, Hengyang Med Sch, Hengyang, Peoples R China.

[Peng, Wang Rui; Chen, Zhiyi] Univ South China, Affiliated Hosp 7, Hunan Vet Adm Hosp, Hengyang Med Sch, Changsha, Peoples R China.

[Saw, Phei Er] Sun Yat Sen Univ, Med Res Ctr,Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangdong Hong Kong Joint Lab RNA Med, Guangzhou, Peoples R China.

[Saw, Phei Er; Saw, PE] Sun Yat Sen Mem Hosp, Nanhai Translat Innovat Ctr Precis Immunol, Foshan, Peoples R China.

[Chen, Zhiyi] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Changsha, Peoples R China.

通讯机构：

[Saw, PE ] S

[Chen, ZY ] U

Univ South China, Inst Med Imaging, Hengyang Med Sch, Hengyang, Peoples R China.

Sun Yat Sen Mem Hosp, Nanhai Translat Innovat Ctr Precis Immunol, Foshan, Peoples R China.

语种：

英文

关键词：

Hydrogel;transdermal drug delivery;therapeutic carrier;burn wound;tissue regeneration

期刊：

Drug Delivery

ISSN：

1071-7544

年：

2024

卷：

期：

页码：

2300945

DOI：

10.1080/10717544.2023.2300945

基金类别：

This work was supported by National Key R&D Program of China (2019YFE0110400), National Natural Science Foundation of China (82272028, 81971621, 82102087), Key R&D Program of Hunan Province (2021SK2035), The Project of Science and Technology Innovation of Hunan Province (2021SK51807), Natural Science Foundation of Hunan Province (2022JJ30039, 2022JJ40392).

机构署名：

本校为第一且通讯机构

摘要：

Burn injuries are prevalent and life-threatening forms that contribute significantly to mortality rates due to associated wound infections. The management of burn wounds presents substantial challenges. Hydrogel exhibits tremendous potential as an ideal alternative to traditional wound dressings such as gauze. This is primarily attributed to its three-dimensional (3D) crosslinked polymer network, which possesses a high water content, fostering a moist environment that supports effective burn wound healing. Additionally, hydrogel facilitates the penetration of loaded therapeutic agents througho...

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Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system

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