Caffeic acid phenethyl ester reverses doxorubicin resistance in breast cancer cells via lipid metabolism regulation at least partly by suppressing the Akt/mTOR/SREBP1 pathway

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成果类型：

期刊论文

作者：

Liang, Lu-Chang;Zhao, Lei;Yu, Bo;Hu, Han-Xiang;He, Xu-Hua;...

作者机构：

[Liang, Lu-Chang; Zhao, Lei] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Gastrointestinal Surg, Hengyang, Hunan, Peoples R China.

[Yu, Bo] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharmaceut, Hengyang, Hunan, Peoples R China.

[He, Xu-Hua; Hu, Han-Xiang] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Urol, Hengyang, Hunan, Peoples R China.

[Zhang, Yan-Min] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pediat, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

Akt/mTOR/SREBP1 pathway;Caffeic acid phenethyl ester;breast cancer;doxorubicin resistance;lipid metabolism

期刊：

KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

ISSN：

1607-551X

年：

2023

卷：

期：

页码：

605-615

DOI：

10.1002/kjm2.12675

基金类别：

Hengyang Science and Technology Planning Bureau [2020jh042751]; Hunan Provincial Health Commission [202104082348]

机构署名：

本校为第一机构

院系归属：

药学与生物科学学院

摘要：

Chemotherapy is one of the common treatment methods for breast cancer, but chemoresistance is a severe challenge. Caffeic acid phenethyl ester (CAPE) is an active ingredient of propolis extract and has been shown to have a variety of beneficial effects, and its potential as a treatment for breast cancer is worth exploring. The effects of CAPE on doxorubicin (DOX) resistance were determined by cell counting kit-8 (CCK-8) assay, colony-formation assay, and flow cytometry. Oil Red O staining and the detection of free fatty acids, triglycerides, phospholipids, and cholesterol were performed to ass...

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Caffeic acid phenethyl ester reverses doxorubicin resistance in breast cancer cells via lipid metabolism regulation at least partly by suppressing the Akt/mTOR/SREBP1 pathway

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