POU2F2-mediated upregulation of lncRNA PTPRG-AS1 inhibits ferroptosis in breast cancer via miR-376c-3p/SLC7A11 axis

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成果类型：

期刊论文

作者：

Li, Jun;Li, Pei-Ting;Wu, Wei;Ding, Bo-Ni;Wen, Yan-Guang;...

通讯作者：

Qian, Li-Yuan;Du, J

作者机构：

[Li, Pei-Ting; Wen, Yan-Guang; Cai, Hai-Lin; Wu, Wei; Ding, Bo-Ni; Li, Jun; Qian, Li-Yuan; Liu, Shuang-Xi; Du, Juan] Cent South Univ, Xiangya Hosp 3, Dept Breast & Thyroid Surg, Changsha 410013, Hunan, Peoples R China.

[Hong, Tao] Nanchang Univ, Affiliated Hosp 2, Dept Breast & Thyroid Surg, Nanchang 330008, Jiangxi, Peoples R China.

[Zhang, Jian-Fei] Univ South China, Affiliated Hosp 2, Dept Plast Surg, Hengyang 421000, Hunan, Peoples R China.

[Zhou, Jian-Da] Cent South Univ, Xiangya Hosp 3, Dept Plast Surg, Changsha 410013, Hunan, Peoples R China.

通讯机构：

[Qian, LY; Du, J ] C

Cent South Univ, Xiangya Hosp 3, Dept Breast & Thyroid Surg, Changsha 410013, Hunan, Peoples R China.

语种：

英文

关键词：

SLC7A11;breast cancer;ferroptosis;lncRNA PTPRG-AS1

期刊：

EPIGENOMICS

ISSN：

1750-1911

年：

2024

卷：

期：

页码：

215-231

DOI：

10.2217/epi-2023-0100

基金类别：

Natural Science Foundation of Hunan Province, China [2022JJ40748]

机构署名：

本校为其他机构

摘要：

Background: Triple-negative breast cancer (TNBC) is a subtype of BC with high rates of mortality. The mechanism of PTPRG-AS1 in ferroptosis of TNBC was investigated. Methods: Chromatin immunoprecipitation and dual-luciferase reporter assays were used to measure intermolecular relationships. MTT and colony formation assays detected cell viability and proliferation. Kits detected Fe2+ and reactive oxygen species levels. The role of PTPRG-AS1 in tumor growth was analyzed in vivo. Results: PTPRG-AS1 was increased in TNBC tissues and cells. PTPRG-AS1 silencing increased the reduction of glutathione...

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POU2F2-mediated upregulation of lncRNA PTPRG-AS1 inhibits ferroptosis in breast cancer via miR-376c-3p/SLC7A11 axis

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