miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Fengzhen;Zhang, Li;Long, Zhe;Chen, Zhao;Hou, Xuan;...

通讯作者：

Jiang, Hong

作者机构：

[Tang, Beisha; Zhang, Li; Wang, Chunrong; Wang, Junling; Jiang, Hong; Huang, Fengzhen; Hou, Xuan; Chen, Zhao; Peng, Huirong; Long, Zhe] Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.

[Tang, Beisha; Jiang, Hong; Duan, Ranhui; Li, Jiada; Xia, Kun] Cent S Univ, State Key Lab Med Genet China, Changsha 410008, Hunan, Peoples R China.

[Tang, Beisha; Jiang, Hong] Cent S Univ, Key Lab Hunan Prov Neurodegenerat Disorders, Changsha 410008, Hunan, Peoples R China.

[Huang, Fengzhen] Univ South China, Peoples Hosp Chenzhou 1, Dept Neurol, Chenzhou, Peoples R China.

[Huang, Fengzhen] Univ South China, Peoples Hosp Chenzhou 1, Inst Translat Med, Chenzhou, Peoples R China.

通讯机构：

[Jiang, Hong] C

Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China.

语种：

英文

关键词：

Spinocerebellar ataxia type 3/Machado–Joseph disease;ATXN3;Cytotoxicity;Neuronal intranuclear inclusion;miR-25;Gene expression regulation

期刊：

FEBS Letters

ISSN：

0014-5793

年：

2014

卷：

588

期：

页码：

4791-4798

DOI：

10.1016/j.febslet.2014.11.013

基金类别：

National Basic Research Program (973 Program)National Basic Research Program of China [2012CB944601, 2012CB517902, 2011CB510002]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81410308019, 81471156, 81271260, 30971585]; Hunan Funds for Distinguished Young Scientists [14JJ1008]; Xinjiang Natural Science Foundation [201318101-4]; High-level medical personnel of Hunan province "225'' Project; Intramural Research Program of the National Institute of Mental Health, National Institutes of Health (IRP-NIMH-NIH); Undergraduate Innovation Project of Central South University [YB13028]; NATIONAL INSTITUTE OF MENTAL HEALTHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) [ZIAMH002468, ZIAMH002468, Z01MH002698, ZIAMH002468, Z01MH002698, ZIAMH002468, Z01MH002698, ZIAMH002468, Z01MH002698, Z01MH002698, Z01MH002698, Z01MH002698, Z01MH002698, ZIAMH002468, Z01MH002698, Z01MH002698, Z01MH002698, Z01MH002698, Z01MH002698, ZIAMH002468] Funding Source: NIH RePORTER

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

MicroRNAs (miRNAs) have been reported to play significant roles in the pathogenesis of various polyQ diseases. This study aims to investigate the regulation of ATXN3 gene expression by miRNA. We found that miR-25 reduced both wild-type and polyQ-expanded mutant ataxin-3 protein levels by interacting with the 3′UTR of ATXN3 mRNA. miR-25 also increased cell viability, decreased early apoptosis, and downregulated the accumulation of mutant ataxin-3 protein aggregates in SCA3/MJD cells. These novel results shed light on the potential role of miR-2...

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miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3

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