Study the effect of CTSD interaction proteins in invasion and metastasis of nasopharyngeal carcinoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Huang, Weiguo;Wang, Yafei;Zeng, Guqing;Yin, Yufang;Ouyang, Chenjie;...

通讯作者：

Cheng, Ailan

作者机构：

[Li, Yu; Wang, Yafei; Cheng, Ailan; Tang, Yunlian; Ouyang, Chenjie; Huang, Weiguo] Univ South China, Canc Res Inst, Hengyang 421001, Peoples R China.

[Wen, Gebo; Huang, Weiguo] Univ South China, Postdoctoral Mobile Stn Preclin Med, Hengyang 421001, Peoples R China.

[Wang, Yafei] First Hosp Qinhuangdao, Dept Pathol, Qinhuangdao 066000, Peoples R China.

[Zeng, Guqing] Univ South China, Sch Nursing, Hengyang 421001, Peoples R China.

[Yin, Yufang] Southern Illinois Univ, Sch Med, Dept Pharmacol, Springfield, IL USA.

通讯机构：

[Cheng, Ailan] U

Univ South China, Canc Res Inst, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Nasopharyngeal carcinoma (NPC);cathepsin D;interacting protein;mass spectrometry (MS);bioinformatics;invasion and metastasis

期刊：

TRANSLATIONAL CANCER RESEARCH

ISSN：

2218-676X

年：

2017

卷：

期：

页码：

1236-1247

DOI：

10.21037/tcr.2017.10.48

基金类别：

Scientific Natural Research Fund of Hunan Provincial Education Department [10A104]; Construct Program of the Key Discipline in Hunan Province [2011-76]; Natural Sciences Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [10JJ6035, 12JJ6080]; Hunan Province Science foundation [2016JJ2012]; National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81372894, 81072198, 81172210, 81272959]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2012M521528]; open fund of Chinese Hunan Provincial Education Department innovation platform [15K109]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

护理学院

摘要：

Background: Cathepsin D is a lysosomal aspartyl protease. Our previous studies have suggested that cathepsin D plays an important role in invasion and metastasis of nasopharyngeal carcinoma (NPC). Methods: To identify proteins that interact with cathepsin D and gain an insight into the role of cathepsin D in invasion and metastasis of NPC, co-immunoprecipitation (co-IP) combined with mass spectrometry (MS)-based proteomics approach was used. Cathepsin D associated proteins were identified by MS. Protein-protein interaction network were analyzed...

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Study the effect of CTSD interaction proteins in invasion and metastasis of nasopharyngeal carcinoma

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