Pokemon Inhibits Transforming Growth Factor beta-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Ling;Zhong, Jing;Liu, Jiang-Hua;Liao, Duan-Fang;Shen, Ying-Ying;...

通讯作者：

Zu, Xu-Yu

作者机构：

[Shen, Ying-Ying; Peng, Xiu-Da; Zhong, Jing; Zhong, Xiao-Lin; Xiao, Xiao; Ding, Wen-Jun; Chen, Ling; Zu, Xu-Yu; Liu, Jiang-Hua] Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Peoples R China.

[Liao, Duan-Fang] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

[Xiong, Wei] Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis, Minist Hlth, Changsha, Hunan, Peoples R China.

[Xiong, Wei] Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Changsha, Hunan, Peoples R China.

通讯机构：

[Zu, Xu-Yu] U

Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Breast neoplasms;Cell proliferation;Pokemon protein, human;SP1;Smad4 protein

期刊：

JOURNAL OF BREAST CANCER

ISSN：

1738-6756

年：

2019

卷：

期：

页码：

15-28

DOI：

10.4048/jbc.2019.22.e11

基金类别：

Major Program of National Health and Family Planning Commission of Hunan [A2017013]; Scientific Research Fund of Education Department of Hunan Province [16B230]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81272355, 81773294]; Guangxi Provincial Natural Science Foundation [2015GXNSFEA139003]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ3464]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Purpose: Pokemon, also known as ZBTB7A, belongs to the POZ and Kruppel (POK) family of transcription repressors and is implicated in tumor progression as a key proto-oncogene. This present study aimed at determining the mechanism by which Pokemon inhibits transforming growth factor beta (TGFbeta)-Smad4 pathway-dependent proliferation arrest of breast cancer cells via specificity protein 1 (SP1). Methods: Over-expressing plasmid or small interfering RNA (siRNA) transfection was used to regulate Pokemon levels. The EdU incorporation assay, MTS assay, and clone formation were used to identify the...

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Pokemon Inhibits Transforming Growth Factor beta-Smad4-Related Cell Proliferation Arrest in Breast Cancer through Specificity Protein 1

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