The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y

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成果类型：

期刊论文

作者：

Ma, Yun*;Tian, Shuai;He, Shuya*;Chen, Qiong;Wang, Zongbao;...

通讯作者：

He, Shuya;Ma, Yun;Lei, Xiaoyong

作者机构：

[He, Shuya; Xiao, Xiao; Fu, Liang; Ma, Yun; Tian, Shuai] Univ South China, Dept Biochem & Biol, 28 Western Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.

[Wang, Zongbao; He, Shuya; Lei, Xiaoyong; Ma, Yun; Lei, XY] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 Western Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.

[Chen, Qiong] Cent S Univ, Xiangya Hosp, Dept Resp, Dept Geriatr Med, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[He, Shuya] U

[Ma, Y; Lei, XY] H

Univ South China, Dept Biochem & Biol, 28 Western Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.

Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, 28 Western Changsheng Rd, Hengyang City 421001, Hunan, Peoples R China.

语种：

英文

关键词：

miR-19b;FXR1;RAB18;USP32;Dusp6

期刊：

Gene

ISSN：

0378-1119

年：

2016

卷：

588

期：

页码：

62-68

DOI：

10.1016/j.gene.2016.04.037

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81200881]; Hunan Provincial Education Department of China [14B158]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [12JJ6073]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

The biological effects of microRNAs (miRNAs) in the Fragile X Syndrome (FXS) have been widely studied. Dysregulation of miRNAs plays a critical role in the progression of nervous system diseases and in cell proliferation and differentiation. Our previous study validated that miR-19b-3p was associated with FXR1 (Fragile X related gene I), one of homologous genes of FMR1 (Fragile X mental retardation 1). The purpose of this study was to investigate the relationship of FXR1 and miR-19b-3p, and the crucial role of miR-19b-3p in FXS and to validate whether miR-19b-3p could regulate the growth of SH...

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The mechanism of action of FXR1P-related miR-19b-3p in SH-SY5Y

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