The neutron in the pressure water reactor (PWR) core scatters on the hydrogen nuclei of the primary coolant to produce the energetic proton, then the proton reacts with the target nuclei in the primary coolant to produce radio-nuclide. In this paper we take the Qinshan second period pressure water reactor as a sample: first, calculate the high energy neutron flux and obtain the proton spectrum; then, calculate the productive rate of the radio-nuclides, which are 13 N produced by 16 O(p, α) 13 N reaction, 18 F produced by 18 O(p, n) 18 F reacti...