Curcumin nicotinate increases LDL cholesterol uptake in hepatocytes through IDOL/LDL-R pathway regulation

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成果类型：

期刊论文

作者：

Huang, Ying;Liu, Fang-yuan;Yang, Jia-tao;Zhao, Qian;Zhu, Mei-qi;...

通讯作者：

Zhang, CP;Lin, Li-mei;Liao, DF

作者机构：

[Liao, Duan-fang; Lin, Li-mei; Tuo, Qin-hui; Huang, Ying] Hunan Univ Chinese Med, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Hunan, Peoples R China.

[Zhu, Mei-qi; Wang, Jing; Zhang, Cai-ping; Long, Shi-yin; Zhao, Qian; Liu, Fang-yuan; Yang, Jia-tao] Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

[Huang, Ying] Shenzhen Samii Med Ctr, Shenzhen 518118, Guangdong, Peoples R China.

[Lin, Li-mei; Liao, DF; Liao, Duan-fang] Hunan Univ Chinese Med, Sch Pharm, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Hanpu Sci & Educ Dist, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Liao, DF ; Lin, LM] H

[Zhang, CP ] U

Univ South China, Hengyang Med Sch, Dept Biochem & Mol Biol, Hengyang 421001, Hunan, Peoples R China.

Hunan Univ Chinese Med, Sch Pharm, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Hanpu Sci & Educ Dist, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

语种：

英文

关键词：

Curcumin nicotinate;Hyperlipidemia;IDOL;Low-density lipoprotein receptor;Rosuvastatin

期刊：

European Journal of Pharmacology

ISSN：

0014-2999

年：

2024

卷：

966

页码：

176352

DOI：

10.1016/j.ejphar.2024.176352

基金类别：

Nature Science Fundation of Hunan Province [2022JJ30513, 2022JJ30454, 2019JJ50503]; Key Project of Hunan Provincial Department of Education [20A379]; Key Special Project of Hunan Provincial Department of Science and Technology [2022SK 2011]; Hunan Science and Technology Innovation Team Project [2021RC4064]; Changsha Science and Technology Project [kq2303001]; First-class Discipline Project on Chinese Pharmacology of Hunan Province; Research Foundation of Shenzhen Samii Medical Center [SSMC-2021-A9, SSMC-2024-A1]

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

BACKGROUND: Curcumin nicotinate (Curtn), derived from curcumin and niacin, reduces serum LDL-C levels, partly due to its influence on PCSK9. This study investigates IDOL's role in Curtn's lipid-lowering effects. OBJECTIVE: To elucidate Curtn's regulation of the IDOL/LDLR pathway and potential molecular mechanisms in hepatocytes. METHODS: Differential metabolites in Curtn-treated HepG2 cells were identified via LC-MS. Molecular docking assessed Curtn's affinity with IDOL. Cholesterol content and LDLR expression effects were studied in high-fat diet Wistar rats. In vitro evaluations determined C...

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Curcumin nicotinate increases LDL cholesterol uptake in hepatocytes through IDOL/LDL-R pathway regulation

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