A Near-Infrared II Luminogen with a Photothermal Effect toward Tumor Drug Resistance Reversal

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成果类型：

期刊论文

作者：

Du, Kaihong;Zhang, Guiquan;He, Dong;Chen, Zhizai;He, Shanyang;...

通讯作者：

Hu, Rong;Qin, AJ;Qin, Anjun;Tang, BZ;Hu, R

作者机构：

[Du, Kaihong; Qin, Anjun; Qin, AJ; Zhang, Guiquan; Hu, Rong; Hu, R] South China Univ Technol, Guangdong Prov Key Lab Luminescence Mol Aggregates, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China.

[Du, Kaihong; Qin, Anjun; Zhang, Guiquan; Hu, Rong; Qin, AJ; Tang, Ben Zhong; Hu, R] South China Univ Technol, Ctr Aggregat Induced Emiss, Mol Aggregates, Guangzhou 510640, Peoples R China.

[Hu, R; Hu, Rong] Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

[Tang, Ben Zhong] Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, CUHK Shenzhen, Shenzhen 518172, Guangdong, Peoples R China.

[He, Dong] Soochow Univ, Affiliated Hosp 1, Dept Urol, Suzhou 215006, Jiangsu, Peoples R China.

通讯机构：

[Qin, AJ ; Qin, AJ; Tang, BZ ; Hu, R] S

[Hu, R ] U

South China Univ Technol, Guangdong Prov Key Lab Luminescence Mol Aggregates, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China.

South China Univ Technol, Ctr Aggregat Induced Emiss, Mol Aggregates, Guangzhou 510640, Peoples R China.

Univ South China, Sch Chem & Chem Engn, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

NIR II;drug-resistant tumor;fluorescent luminogen;photothermal therapy;reversal

期刊：

ACS Applied Materials & Interfaces

ISSN：

1944-8244

年：

2025

卷：

期：

页码：

333–341

DOI：

10.1021/acsami.4c14811

基金类别：

National Natural Science Foundation of China [21788102, 21901075]; National Natural Science Foundation of China [2023B1212060003]; Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates [2024B0101040001]; Key-Area Research and Development Program of Guangdong Province [2024ZYGXZR004]; Fundamental Research Funds for the Central Universities [ITC-CNERC14SC01]; Innovation and Technology Commission of Hong Kong

机构署名：

本校为通讯机构

院系归属：

化学化工学院

摘要：

Multidrug resistance of tumor cells has greatly limited the chemotherapy effect. The development of reliable strategies to deal with tumor multidrug resistance is highly desirable for tumor therapy. In this work, a near-infrared II (NIR II) luminogen was rationally designed and prepared, which could act as a photothermal reagent to reverse the drug resistance of tumor cells by reducing the related protein expression, achieving a high inhibition efficiency with the synergistic effect of chemotherapeutic drugs. By the selection of a strong electron-withdrawing unit, the emission peak of the lumi...

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A Near-Infrared II Luminogen with a Photothermal Effect toward Tumor Drug Resistance Reversal

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