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Research and Progress of Probucol in Nonalcoholic Fatty Liver Disease

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成果类型:
期刊论文
作者:
Chen, Ke-Qian;Ke, Bo-Yi;Cheng, Lu;Guan, Meng-Ting;Wang, Zong-bao;...
作者机构:
Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China
Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China
Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China
[Chen, Ke-Qian] Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China <&wdkj&> Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China
[Ke, Bo-Yi; Cheng, Lu; Guan, Meng-Ting; Wang, Zong-bao; Wang, Shu-zhi] Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China <&wdkj&> Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China
语种:
英文
关键词:
Non-alcoholic fatty liver disease;probucol;non-alcoholic steatohepatitis steatosis;fibrosis;mitochondrial dysfunction;(HDL-C).
期刊:
MINI-REVIEWS IN MEDICINAL CHEMISTRY
ISSN:
1389-5575
年:
2023
卷:
23
期:
19
页码:
1905-1911
机构署名:
本校为第一机构
院系归属:
药学与生物科学学院
摘要:
With the development of the social economy over the last 30 years, non-alcoholic fatty liver disease (NAFLD) is affected by unhealthy living habits and eating styles and has gradually become an increasingly serious public health problem. It is very important to investigate the pathogenesis and treatment of NAFLD for the development of human health. Probucol is an antioxidant with a bis-phenol structure. Although probucol is a clinically used cholesterol-lowering and anti-atherosclerosis drug, its mechanism has not been elucidated in detail. This paper reviews the chemical structure, pharmacoki...

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