COX-2 in liver fibrosis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Hu Yang;Yang Xuefeng;Wu Shandong;Xiao Jianhua*

通讯作者：

Xiao Jianhua

作者机构：

[Hu Yang; Xiao Jianhua] Univ South China, Hengyang Med Coll, Inst Pathogen Biol, Hengyang 421001, Hunan, Peoples R China.

[Hu Yang; Xiao Jianhua] Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Hunan, Peoples R China.

[Hu Yang; Xiao Jianhua] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Hunan, Peoples R China.

[Hu Yang; Yang Xuefeng] Univ South China, Affiliated Nanhua Hosp, Dept Gastroenterol, Hengyang 421002, Hunan, Peoples R China.

[Wu Shandong] Univ Alberta, Fac Sci, Dept Pharmacol, Edmonton, AB T6G 2S2, Canada.

通讯机构：

[Xiao Jianhua] U

Univ South China, Med Coll, Inst Pathogen Biol, 28W Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

COX-2;autophagy;cell senescence;inflammation;liver fibrosis

期刊：

Clinica Chimica Acta

ISSN：

0009-8981

年：

2020

卷：

506

页码：

196-203

DOI：

10.1016/j.cca.2020.03.024

基金类别：

The authors gratefully acknowledge the financial support from the Program for Science and Technology Department of Hunan Province ( 2018DK51707 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

As a vital inducible sensor, cyclooxygenase-2 (COX-2) plays an important role in the progress of hepatic fibrogenesis. Activation of hepatic stellate cells (HSCs) in the liver can significantly accelerate the onset and development of liver fibrosis. COX-2 overexpression triggers inflammation that is an important inducer in hepatic fibrosis. Increasing evidence indicates that COX-2 is involved in the main pathogenesis of liver fibrosis, such as inflammation, apoptosis, and cell senescence. Moreover, COX-2 expression is altered in patients and an...

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