Leptin mediates protection of hydrogen sulfide against 6-hydroxydopamine-induced Parkinson\'s disease: Involving enhancement in Warburg effect - 成果

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Leptin mediates protection of hydrogen sulfide against 6-hydroxydopamine-induced Parkinson's disease: Involving enhancement in Warburg effect

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yang, San-Qiao;Tian, Qing;Li, Dan;He, Shi-Qing;Hu, Min;...

通讯作者：

Tang, Xiao-Qing;Liu, Shu-Yun

作者机构：

[Yang, San-Qiao; Tang, Xiao-Qing] Univ South China, Affiliated Hosp 1, Hengyang Med Coll, Inst Neurol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Yang, San-Qiao; Tang, Xiao-Qing; Chen, Yong-Jun; Zou, Wei; Zhang, Ping; Tian, Qing] Univ South China, Hengyang Med Coll, Inst Neurosci, Hengyang 421001, Hunan, Peoples R China.

[Li, Dan; Liu, Shu-Yun] Guangdong Med Univ, Affiliated Ctr Hosp Shenzhen Longhua New Dist, Dept Neurol, 187 Guanlan Ave, Shenzhen 518110, Guangdong, Peoples R China.

[He, Shi-Qing] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Coll, Dept Neurosurg, Hengyang 421001, Hunan, Peoples R China.

[Hu, Min; Chen, Yong-Jun; Zou, Wei; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Coll, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Tang, Xiao-Qing] U

[Liu, Shu-Yun] G

Univ South China, Affiliated Hosp 1, Hengyang Med Coll, Inst Neurol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

Guangdong Med Univ, Affiliated Ctr Hosp Shenzhen Longhua New Dist, Dept Neurol, 187 Guanlan Ave, Shenzhen 518110, Guangdong, Peoples R China.

语种：

英文

关键词：

hexokinase;hexokinase 2;hydrogen sulfide;lactate dehydrogenase;lactic acid;leptin;oxidopamine;pyruvate dehydrogenase;pyruvate dehydrogenase kinase;pyruvate kinase;pyruvate kinase m 2;unclassified drug;hydrogen sulfide;leptin;neuroprotective agent;oxidopamine;adult;aerobic glycolysis;animal cell;animal experiment;animal model;animal tissue;Article;controlled study;cylinder test;dopaminergic nerve cell;enzyme activity;enzyme linked immunosorbent assay;immunohistochemistry;male;neuroprotection;nonhuman;open field test;Parkinson disease;priority journal;protein expression;rat;signal transduction;substantia nigra;upregulation;Western blotting;animal;dose response;drug effect;metabolism;parkinsonism;randomization;Sprague Dawley rat;Animals;Dose-Response Relationship, Drug;Hydrogen Sulfide;Leptin;Male;Neuroprotective Agents;Oxidopamine;Parkinsonian Disorders;Random Allocation;Rats;Rats, Sprague-Dawley;Warburg Effect, Oncologic

期刊：

Neurochemistry International

ISSN：

0197-0186

年：

2020

卷：

135

页码：

104692

DOI：

10.1016/j.neuint.2020.104692

基金类别：

This study was supported by National Natural Science Foundation of China ( 81771178 ), Natural Science Foundation of Guangdong Province of China ( 2014A030313738 ), and the project of Economic Services Bureau of Shenzhen Longhua New District ( 20140917A1030046 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: Hydrogen sulfide (H2S) has therapeutic effects on Parkinson's disease (PD). Warburg effect, namely aerobic glycolysis, is benefit to PD. Leptin, a hormone secreted in adipose, plays an important role in the treatment of PD. Objective: To determine whether the mechanism underlying protection of H2S against PD is involved in promoting Warburg effect via upregulation of leptin. Methods: We set a PD model via unilateral intrastriatal injection of 6-hydroxydopamine (6-OHDA) in Sprague Dawley rat. PD-like behavior was analyzed by apomorph...

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Leptin mediates protection of hydrogen sulfide against 6-hydroxydopamine-induced Parkinson's disease: Involving enhancement in Warburg effect

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