This study was supported by grants from the National Natural Science Foundation of China (Grant Nos.: 81470434 and 81670265) and Cooperative Innovation Center for Molecular Target New Drug Study Postgraduate Innovative Experimental Project in University of South China.
机构署名：
本校为第一且通讯机构
院系归属：
药学与生物科学学院
摘要：
Apelin is the endogenous ligand for the G protein-coupled receptor APJ. Both apelin and APJ receptor are distributed in vascular smooth muscle cells (VSMCs) and play important roles in the cardiovascular system. Our previous reports have indicated that apelin-13 promoted the proliferation of VSMCs, but its exact mechanism remains to be further explored. The results of the present study demonstrated that the Warburg effect plays a pivotal role in apelin-13-induced human aortic vascular smooth muscle cells (HA-VSMCs) proliferation. Apelin-13 prom...
