National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81200217, 81370376]; Natural Science Foundation of Hunan provinceNatural Science Foundation of Hunan Province [2015JJ4097]; Project of Science and Technology Department of Hunan Province [2015JC3081, 2014FJ3015]; Educational Department of Hunan Province Fund for Distinguished Young Scholars [16B228]; Hunan Provincial Innovation Foundation For Postgraduate [CX2016B477]; Construct Program of the Key Discipline in Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Background: Hyperlipidemia is a risk factor for neurodegenerative diseases. Proprotein convertase subtilisin/Kexin type 9 (PCSK9) degrades hepatic low-density lipoprotein receptor (LDLR) to regulate lipid metabolism. It is unclear if PCSK9 plays a role in neurodegenerative diseases. Objective: This study was designed to determine whether PCSK9 is crucial between hyperlipidemia and Alzheimer's disease. The interrelationship between PCSK9 and neuronal apoptosis was explored in PC12 cells in response to treatment with oxidized low-density lipoprot...