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PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway

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成果类型:
期刊论文
作者:
Liu, Lu-Shan;Bai, Xue-Qin;Gao, Ya;Wu, Qi;Ren, Zhong;...
通讯作者:
Tang, Zhi-Han
作者机构:
[Gao, Ya; Wu, Qi; Ren, Zhong; Li, Qing; Tang, Zhi-Han; He, Ni-Ya; Pan, Li-Hong; Peng, Juan; Liu, Lu-Shan; Bai, Xue-Qin] Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Tang, Zhi-Han] U
Univ South China, Key Lab Arteriosclerol Hunan Prov, Inst Cardiovasc Dis, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
amyloid beta protein[1-40];amyloid beta protein[1-42];beta secretase 1;caspase 3;caspase 9;fat droplet;messenger RNA;oxidized low density lipoprotein;proprotein convertase 9;protein Bax;protein bcl 2;small interfering RNA;amyloid beta protein;amyloid beta protein[1-40];amyloid beta-protein (1-42);caspase;low density lipoprotein;messenger RNA;oxidized low density lipoprotein;PCSK9 protein, rat;peptide fragment;proprotein convertase 9;protein Bax;protein bcl 2;serum-free medium;small interfering RNA;Alzheimer disease;animal cell;apoptosis;Article;controlled study;enzyme linked immunosorbent assay;flow cytometry;gene expression;hyperlipidemia;lipid storage;nonhuman;PC12 cell line;priority journal;protein expression;signal transduction;treatment response;upregulation;Western blotting;analysis of variance;animal;apoptosis;dose response;drug effects;genetic transfection;genetics;lipid metabolism;metabolism;pharmacology;rat;serum-free medium;signal transduction;Amyloid beta-Peptides;Analysis of Variance;Animals;Apoptosis;bcl-2-Associated X Protein;Caspases;Culture Media, Serum-Free;Dose-Response Relationship, Drug;Flow Cytometry;Lipid Metabolism;Lipoproteins, LDL;PC12 Cells;Peptide Fragments;Proprotein Convertase 9;Proto-Oncogene Proteins c-bcl-2;Rats;RNA, Messenger;RNA, Small Interfering;Signal Transduction;Transfection
期刊:
JOURNAL OF ALZHEIMERS DISEASE
ISSN:
1387-2877
年:
2017
卷:
57
期:
3
页码:
723-734
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81200217, 81370376]; Natural Science Foundation of Hunan provinceNatural Science Foundation of Hunan Province [2015JJ4097]; Project of Science and Technology Department of Hunan Province [2015JC3081, 2014FJ3015]; Educational Department of Hunan Province Fund for Distinguished Young Scholars [16B228]; Hunan Provincial Innovation Foundation For Postgraduate [CX2016B477]; Construct Program of the Key Discipline in Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Background: Hyperlipidemia is a risk factor for neurodegenerative diseases. Proprotein convertase subtilisin/Kexin type 9 (PCSK9) degrades hepatic low-density lipoprotein receptor (LDLR) to regulate lipid metabolism. It is unclear if PCSK9 plays a role in neurodegenerative diseases. Objective: This study was designed to determine whether PCSK9 is crucial between hyperlipidemia and Alzheimer's disease. The interrelationship between PCSK9 and neuronal apoptosis was explored in PC12 cells in response to treatment with oxidized low-density lipoprot...

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